Cutaneous wound healing requires a well-orchestrated integration of the complex biological and molecular events of cell migration and proliferation. Activation of epithelial stem cells and efficient recruitment of their proliferating progeny plays a critical role in cutaneous wound healing. Transcriptome and multi-omics sequencing technologies have been widely used to identify therapeutic targets for stem cell interventions, as well as to identify diagnostic markers for skin diseases, which provide tremendous opportunities to identify targets, genes and pathways of actions associated with skin diseases. In addition, it also unravels underlying mechanisms of skin diseases and improves stem cell personalized therapeutic regimens.
Specifically, the application of multi-omics has helped us to precisely identify the molecular mechanisms and targets of stem cells and their derivatives in the treatment of skin diseases. The elucidation of the mechanisms has helped us to better improve the performance of stem cells and their derivatives with therapeutic properties, as well as immunogenicity, efficacy and safety. Additionally, bioinformatics needs to be combined with other verification methods such as cell experiments or animal experiments to improve our knowledge of stem cells.
With the application of multi-omics sequencing technologies in skin diseases with stem cells and their related derivatives, treatment of skin diseases becomes promising. However, many questions and challenges remain to be addressed. In particular, the number of known skin disease-related targets is still very limited. There is an urgent need to identify the mechanisms and potential molecular, as well as stem cell targets of action in the genome, transcriptome and epigenome that influences skin disease progression. These targeted genes could become biomarkers for skin disease diagnosis, prognosis, and stem cell therapy. Additionally, as the complexity and heterogeneity of skin diseases largely hinder the efficacy of stem cells, the existing stem cell therapeutic approaches need to be further investigated, in terms of clinical safety, efficacy, and feasibility on the regulation of the immune microenvironment. Therefore, further understanding of the immunomodulatory functions of stem cells in skin diseases and their potential mechanisms of action is urgent, and these discoveries and innovations will further accelerate the effectiveness and efficacy of stem cells therapies for skin diseases.
The aim of this Research Topic is to encourage new discoveries about stem cell therapy through new multi-omics techniques and advances in stem cell therapies for wound repair and skin diseases.
We welcome the submission of Original Research Articles, Reviews, and Mini-reviews, including but not limited to the following topics:
1) Stem cell-mediated tissue regeneration and disease modeling
2) Stem cell differentiation approaches and mechanisms
3) The mechanisms of stem cell-mediated tissue regeneration
4) Biomarkers of stem cell therapy in skin injury and tissue regeneration
5) Computational and bioinformatics techniques for skin cancer
6) Recent research about stem cell precise therapy
7) Application of bioinformatics methods in skin tissue regeneration
8) The recent research about the combination of the stem cells and other therapy
Cutaneous wound healing requires a well-orchestrated integration of the complex biological and molecular events of cell migration and proliferation. Activation of epithelial stem cells and efficient recruitment of their proliferating progeny plays a critical role in cutaneous wound healing. Transcriptome and multi-omics sequencing technologies have been widely used to identify therapeutic targets for stem cell interventions, as well as to identify diagnostic markers for skin diseases, which provide tremendous opportunities to identify targets, genes and pathways of actions associated with skin diseases. In addition, it also unravels underlying mechanisms of skin diseases and improves stem cell personalized therapeutic regimens.
Specifically, the application of multi-omics has helped us to precisely identify the molecular mechanisms and targets of stem cells and their derivatives in the treatment of skin diseases. The elucidation of the mechanisms has helped us to better improve the performance of stem cells and their derivatives with therapeutic properties, as well as immunogenicity, efficacy and safety. Additionally, bioinformatics needs to be combined with other verification methods such as cell experiments or animal experiments to improve our knowledge of stem cells.
With the application of multi-omics sequencing technologies in skin diseases with stem cells and their related derivatives, treatment of skin diseases becomes promising. However, many questions and challenges remain to be addressed. In particular, the number of known skin disease-related targets is still very limited. There is an urgent need to identify the mechanisms and potential molecular, as well as stem cell targets of action in the genome, transcriptome and epigenome that influences skin disease progression. These targeted genes could become biomarkers for skin disease diagnosis, prognosis, and stem cell therapy. Additionally, as the complexity and heterogeneity of skin diseases largely hinder the efficacy of stem cells, the existing stem cell therapeutic approaches need to be further investigated, in terms of clinical safety, efficacy, and feasibility on the regulation of the immune microenvironment. Therefore, further understanding of the immunomodulatory functions of stem cells in skin diseases and their potential mechanisms of action is urgent, and these discoveries and innovations will further accelerate the effectiveness and efficacy of stem cells therapies for skin diseases.
The aim of this Research Topic is to encourage new discoveries about stem cell therapy through new multi-omics techniques and advances in stem cell therapies for wound repair and skin diseases.
We welcome the submission of Original Research Articles, Reviews, and Mini-reviews, including but not limited to the following topics:
1) Stem cell-mediated tissue regeneration and disease modeling
2) Stem cell differentiation approaches and mechanisms
3) The mechanisms of stem cell-mediated tissue regeneration
4) Biomarkers of stem cell therapy in skin injury and tissue regeneration
5) Computational and bioinformatics techniques for skin cancer
6) Recent research about stem cell precise therapy
7) Application of bioinformatics methods in skin tissue regeneration
8) The recent research about the combination of the stem cells and other therapy