It has been proposed that Cortico-Basal Ganglia circuits (CBG) have distinct networks and functions. Accumulated anatomical studies and physiological studies support that the basal ganglia have different sub-territories (i.e., motor, associative, and limbic territories), which have connections with the associated cortical areas via the thalamus. Research in animal-disease models and human patients has revealed that dysfunctions of individual sub-territory can cause abnormal behaviors, such as involuntary movements, attention deficits, stereotypy, and anxiety. Aberrant neuronal activity in the CBG may also explain psychiatric symptoms observed in Parkinson’s disease (PD), obsessive-compulsive disorder (OCD), addiction, depression, schizophrenia, and autism. However, neural mechanisms of psychiatric disorders remain unsolved mysteries. We, therefore, emphasize that it is necessary to comprehensively understand the functions and dysfunctions of the CBG.
The CBG system has been extensively investigated in the motor system, due to the strong relevance of motor disorders such as PD, Huntington’s disease, and Tourette's Syndrome. However, in the past few decades, many studies have explored the cognitive and emotional functions of the CBG. Furthermore, clinical evidence has accumulated that the dysfunctions of the CBG can cause psychiatric symptoms, as seen in patients with OCD, addiction, depression, schizophrenia, and autism. The primary goal of this Research Topic is to comprehensively review the associative and limbic domains of the CBG in addition to the classic motor domain. To this end, we widely welcome basic and clinical neuroscientists to deepen our knowledge related to the CBG and to develop cutting-edge diagnoses and treatments for psychiatric disorders. A variety of researchers working in different fields (molecule, synapse, neuron and glia, neural circuits, imaging, behavior) are welcome.
In this Research Topic, we ask a wide range of contributions from international scientists to review and update recent findings related to the CBG from the molecular level to the clinical. We would like to collect original contributions to review articles that include current research findings and advanced opinions. We welcome to receive manuscript related to
• Cortico-Basal Ganglia circuits (anatomy and physiology)
• Molecular, synaptic, cellular, and circuit mechanisms of motor and psychiatric disorders (attention deficits, stereotypy, and anxiety, etc.)
• Animal-disease models and human clinical studies (including EEG, PET, MEG, fMRI, etc.) related to motor and psychiatric disorders -Parkinson’s disease (PD), obsessive-compulsive disorder (OCD), anxiety disorder, depression, schizophrenia, addiction, Tourette's syndrome, and autisms.
• Research that could explain pathological mechanisms of CBG in animal and human healthy subjects.
Topic Editor Dr. Yosuke Saga is currently employed at Janssen Pharma KK. The other Topic Editors declare no competing conflicts of interest.
It has been proposed that Cortico-Basal Ganglia circuits (CBG) have distinct networks and functions. Accumulated anatomical studies and physiological studies support that the basal ganglia have different sub-territories (i.e., motor, associative, and limbic territories), which have connections with the associated cortical areas via the thalamus. Research in animal-disease models and human patients has revealed that dysfunctions of individual sub-territory can cause abnormal behaviors, such as involuntary movements, attention deficits, stereotypy, and anxiety. Aberrant neuronal activity in the CBG may also explain psychiatric symptoms observed in Parkinson’s disease (PD), obsessive-compulsive disorder (OCD), addiction, depression, schizophrenia, and autism. However, neural mechanisms of psychiatric disorders remain unsolved mysteries. We, therefore, emphasize that it is necessary to comprehensively understand the functions and dysfunctions of the CBG.
The CBG system has been extensively investigated in the motor system, due to the strong relevance of motor disorders such as PD, Huntington’s disease, and Tourette's Syndrome. However, in the past few decades, many studies have explored the cognitive and emotional functions of the CBG. Furthermore, clinical evidence has accumulated that the dysfunctions of the CBG can cause psychiatric symptoms, as seen in patients with OCD, addiction, depression, schizophrenia, and autism. The primary goal of this Research Topic is to comprehensively review the associative and limbic domains of the CBG in addition to the classic motor domain. To this end, we widely welcome basic and clinical neuroscientists to deepen our knowledge related to the CBG and to develop cutting-edge diagnoses and treatments for psychiatric disorders. A variety of researchers working in different fields (molecule, synapse, neuron and glia, neural circuits, imaging, behavior) are welcome.
In this Research Topic, we ask a wide range of contributions from international scientists to review and update recent findings related to the CBG from the molecular level to the clinical. We would like to collect original contributions to review articles that include current research findings and advanced opinions. We welcome to receive manuscript related to
• Cortico-Basal Ganglia circuits (anatomy and physiology)
• Molecular, synaptic, cellular, and circuit mechanisms of motor and psychiatric disorders (attention deficits, stereotypy, and anxiety, etc.)
• Animal-disease models and human clinical studies (including EEG, PET, MEG, fMRI, etc.) related to motor and psychiatric disorders -Parkinson’s disease (PD), obsessive-compulsive disorder (OCD), anxiety disorder, depression, schizophrenia, addiction, Tourette's syndrome, and autisms.
• Research that could explain pathological mechanisms of CBG in animal and human healthy subjects.
Topic Editor Dr. Yosuke Saga is currently employed at Janssen Pharma KK. The other Topic Editors declare no competing conflicts of interest.
