In recent years, neuroinflammation is attracting increasing research attention as a common thread in neurological disorders. Neuroinflammation is usually defined as an inflammatory reaction/immune response in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the central nervous system. It is a complex response involving activation of glial cells, secretion of inflammatory mediators, and production of reactive oxygen and nitrogen species. As mentioned above, neuroinflammation has been shown to contribute to several acute and chronic neurological disorders, such as stroke, Alzheimer’s disease, depression, and even brain tumor et al, and many therapeutic breakthroughs in neurological disease have been immune-targeted. So, there is a need to elucidate the molecular mechanisms underlying neuroinflammation. More recently, the non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piRNAs (PIWI-interacting RNAs) are demonstrated to be highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes including neuroinflammation. However, the potential role of ncRNAs in neuroinflammation remains largely unknown.
This Research Topic aims at promoting a better understanding in the regulatory role and molecular interaction of ncRNA in neuroinflammation and providing new insights into their translational application. We welcome Original Research articles, Methods, Reviews, Mini Reviews, Perspectives, and Opinions on the sub-themes below:
- Molecular interaction and mechanism of non-coding RNA in the occurrence and progression of neuroinflammation
- Novel ncRNA biomarkers for neuroinflammation
- Novel biological functions of non-coding RNA in neuroinflammation (i.e., protein translation)
- Non-coding RNA modifications (i.e., m6A methylation) in neuroinflammation
- Novel therapeutic targets for the treatment of neuroinflammation
In recent years, neuroinflammation is attracting increasing research attention as a common thread in neurological disorders. Neuroinflammation is usually defined as an inflammatory reaction/immune response in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the central nervous system. It is a complex response involving activation of glial cells, secretion of inflammatory mediators, and production of reactive oxygen and nitrogen species. As mentioned above, neuroinflammation has been shown to contribute to several acute and chronic neurological disorders, such as stroke, Alzheimer’s disease, depression, and even brain tumor et al, and many therapeutic breakthroughs in neurological disease have been immune-targeted. So, there is a need to elucidate the molecular mechanisms underlying neuroinflammation. More recently, the non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and piRNAs (PIWI-interacting RNAs) are demonstrated to be highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes including neuroinflammation. However, the potential role of ncRNAs in neuroinflammation remains largely unknown.
This Research Topic aims at promoting a better understanding in the regulatory role and molecular interaction of ncRNA in neuroinflammation and providing new insights into their translational application. We welcome Original Research articles, Methods, Reviews, Mini Reviews, Perspectives, and Opinions on the sub-themes below:
- Molecular interaction and mechanism of non-coding RNA in the occurrence and progression of neuroinflammation
- Novel ncRNA biomarkers for neuroinflammation
- Novel biological functions of non-coding RNA in neuroinflammation (i.e., protein translation)
- Non-coding RNA modifications (i.e., m6A methylation) in neuroinflammation
- Novel therapeutic targets for the treatment of neuroinflammation
