As one of the most prevalent causes of chronic liver disease, non-alcoholic fatty liver disease (NAFLD) refers to the clinical metabolic syndrome with excessive fat deposition in the liver due to high fat diet and ranges from simple steatosis to nonalcoholic steatohepatitis; the latter can develop to progressive fibrosis and hepatocellular carcinoma. NAFLD is a risk factor for many metabolic diseases, including type 2 diabetes, obesity, hyperuricemia, hypertension, and cardiovascular diseases. Therefore, effective therapies for treating NAFLD are urgently needed to prevent its further development into more severe metabolic diseases. Polyphenols have shown strong antioxidant, anti-inflammatory and anti-apoptotic properties due to the special structure. Because Inflammation and oxidative stress are the main risk factors involved in the pathogenesis of NAFLD, recent studies suggest that consuming polyphenol-rich diets may have a role in the prevention and treatment of NAFLD.
This Research Topic aims to bring together the results of fundamental and applied research into bioactive compounds especially polyphenols, and also contribute to filling the gap in the knowledge about the protective effects and the underlying mechanisms of dietary polyphenols against non-alcoholic fatty liver disease (NAFLD).
We welcome papers from researchers in the fields of the following themes:
• Innovative polyphenols (flavonoids, phenolic acid, alkaloids, tannins, etc.) which can show protective effects against non-alcoholic fatty liver disease (NAFLD);
• Analyze the composition of polyphenols in extracts or bioactive compounds that showed protective effects against NAFLD
• Explore the protective mechanisms from the aspects about glucose metabolism, lipid metabolism, inflammatory stress, apoptosis, gut microbiota, transcriptomics, proteomics, metabolomics, etc.
As one of the most prevalent causes of chronic liver disease, non-alcoholic fatty liver disease (NAFLD) refers to the clinical metabolic syndrome with excessive fat deposition in the liver due to high fat diet and ranges from simple steatosis to nonalcoholic steatohepatitis; the latter can develop to progressive fibrosis and hepatocellular carcinoma. NAFLD is a risk factor for many metabolic diseases, including type 2 diabetes, obesity, hyperuricemia, hypertension, and cardiovascular diseases. Therefore, effective therapies for treating NAFLD are urgently needed to prevent its further development into more severe metabolic diseases. Polyphenols have shown strong antioxidant, anti-inflammatory and anti-apoptotic properties due to the special structure. Because Inflammation and oxidative stress are the main risk factors involved in the pathogenesis of NAFLD, recent studies suggest that consuming polyphenol-rich diets may have a role in the prevention and treatment of NAFLD.
This Research Topic aims to bring together the results of fundamental and applied research into bioactive compounds especially polyphenols, and also contribute to filling the gap in the knowledge about the protective effects and the underlying mechanisms of dietary polyphenols against non-alcoholic fatty liver disease (NAFLD).
We welcome papers from researchers in the fields of the following themes:
• Innovative polyphenols (flavonoids, phenolic acid, alkaloids, tannins, etc.) which can show protective effects against non-alcoholic fatty liver disease (NAFLD);
• Analyze the composition of polyphenols in extracts or bioactive compounds that showed protective effects against NAFLD
• Explore the protective mechanisms from the aspects about glucose metabolism, lipid metabolism, inflammatory stress, apoptosis, gut microbiota, transcriptomics, proteomics, metabolomics, etc.