Both emotional stressors and physical injury trigger adaptive endocrine, immune, metabolic, and neuronal responses that lead to cognitive, emotional and behavioural changes that are essential for survival. However, these responses to stress and injury can sometime persist beyond biological usefulness and become maladaptive, leading to adverse neuropsychiatric outcomes including chronic pain, anxiety, and depression. These long-term sequelae are often overlapping, suggesting shared underlying mechanisms. Increased understanding of the underlying biology that drives the development of these outcomes and the interactions between stress and pain could help in the identification of novel therapeutics for the treatment of chronic pain.
This Research Topic in the Frontiers in Pain Research will explore the neurobiological mechanisms underlying the interactions between stress and pain with the aim to identify novel treatment strategies.
We invite submissions of both original research, opinions and review articles including, but not limited to, the following:
• Preclinical and clinical studies examining mechanisms underlying stress, pain and/or their interactions
• Pharmacological and/or genetic modulation of stress-pain interactions
• Biomarkers of stress associated pain states
• Impact of sex and race on stress-pain interactions
Both emotional stressors and physical injury trigger adaptive endocrine, immune, metabolic, and neuronal responses that lead to cognitive, emotional and behavioural changes that are essential for survival. However, these responses to stress and injury can sometime persist beyond biological usefulness and become maladaptive, leading to adverse neuropsychiatric outcomes including chronic pain, anxiety, and depression. These long-term sequelae are often overlapping, suggesting shared underlying mechanisms. Increased understanding of the underlying biology that drives the development of these outcomes and the interactions between stress and pain could help in the identification of novel therapeutics for the treatment of chronic pain.
This Research Topic in the Frontiers in Pain Research will explore the neurobiological mechanisms underlying the interactions between stress and pain with the aim to identify novel treatment strategies.
We invite submissions of both original research, opinions and review articles including, but not limited to, the following:
• Preclinical and clinical studies examining mechanisms underlying stress, pain and/or their interactions
• Pharmacological and/or genetic modulation of stress-pain interactions
• Biomarkers of stress associated pain states
• Impact of sex and race on stress-pain interactions
