Pain is a complex phenomenon that varies hugely between patients, in the underlying mechanisms and treatment responses, which renders diagnosis, treatment, prevention and management of pain very challenging. Studies have shown that over 100 million patients in the United States suffer from persistent pain, and 1 in 5 individuals experience a form of chronic pain. Another challenge faced by pain researchers and clinicians is the wide variability in the individual pain experience, as it is subjective. Acute pain is self-limiting; it is generally caused by disease, inflammation or injury to tissues, and occurs suddenly, as a result of trauma or surgery. Chronic pain can result from acute pain; it persists for a long period of time, may become resistant to many treatments and lead to more severe conditions such as widespread pain or multiple pain disorders.
The underlying neurophysiological pathways in acute and chronic pain are complex and still not fully understood. Elucidation of central and peripheral nervous system mechanisms driving pain is important, in order to advance knowledge and development of novel analgesic treatments. Research investigating the role of temporal and spatial summation in conditions of widespread pain is also clinically relevant.
There are many forms of debilitating pain disorders. Musculoskeletal conditions include low back pain, arthritic pain, orofacial pain with temporomandibular joint disorders (TMJD), and widespread fibromyalgia. Cancer pain conditions includes neoplasm-induced pain or pain caused as a result of anticancer treatment. Neuropathic pain results from nerve injury in the central or peripheral nervous system such as post-operative pain, diabetic neuropathy or postherpetic neuralgia. Headaches are another huge area of pain research, including cluster headaches, migraines and tension headaches.
The future of pain research will aim to refine our current understanding of pain mechanisms and elucidate the pathophysiology contributing to acute and chronic pain; in order to help prevent the persistence of pain and develop better treatments. The primary goal is to formulate more effective pharmaceutical drugs that target specific pathways or prevent pain signals from being amplified by the nervous system; and reduce the demand for opioids. Novel approaches include targeting receptors as gateways for pain drugs, modifying ion channels that transmit pain signals, inhibiting trophic factor/receptor interactions and preventing maladaptive plasticity/pain modulation through targeting non-neuronal glial cells and inhibiting their influence on nervous system sensitization.
The journal Frontiers in Pain Research aims to encourage and disseminate high-quality pain research that challenges old and existing theories of mechanisms and treatment. The journal will take a holistic perspective covering mechanisms, treatments, socioeconomics, diagnostics, preventative measures and pain management in a range of medical specialties such as rheumatology and orthopaedics. All studies contributing insights to the pathophysiology of pain and development of novel analgesics for improved clinical treatment and patient quality of life, will be welcome in this journal.
Short Name: Front. Pain Res.
Electronic ISSN: coming soon
Indexed in: Google Scholar, CrossRef
PMCID: coming soon for all published articles
Frontiers in Pain Research is composed of the following Specialty Sections:
The specialty sections of Frontiers in Pain Research welcome submission of the following article types: Brief Research Report, Correction, Data Report, Editorial, Field Grand Challenge, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Policy and Practice Reviews, Policy Brief, Review, Specialty Grand Challenge and Systematic Review.
When submitting a manuscript to Frontiers in Pain Research, authors must submit the material directly to one of the specialty sections. Manuscripts are peer-reviewed by the Associate and Review Editors of the respective specialty section.
Avenue du Tribunal Fédéral 34
CH – 1005 Lausanne
Tel +41(0)21 510 17 40
Fax +41 (0)21 510 17 01
For all queries regarding manuscripts in Review and potential conflicts of interest, please contact firstname.lastname@example.org
For queries regarding Research Topics, Editorial Board applications, and journal development, please contact email@example.com