Gynecological malignancies are the second most common cancer in women all over the world, and their incidence tends to be higher among younger women. Although great progress has been made in the prevention and treatment of gynecological malignancies in recent years, there is still a lack of effective treatment in an advanced stage, which seriously threatens women's health. Pyroptosis, as programmed cell death, participates in tumor proliferation, invasion, and metastasis. In recent years, it has become a new hotspot in tumor research. Tumor cells colonized in normal tissues can form tumor microenvironment (TME) together with stromal cells, immune cells and their secretory factors, vascular endothelial cells, and extracellular matrix. These immune cells and related stromal components form an anti-tumor inflammatory microenvironment in the early stage of tumor colonization or growth, which hinders the occurrence and development of tumors. Further, exploring the role of pyroptosis and TME in the occurrence and development of gynecological malignancies will provide a new strategy for the treatment of gynecological malignancies.
This Research Topic focuses on the relationship between pyroptosis and TME, as well as their interaction in the progression of gynecological malignancies. The purpose is to clarify the biological mechanism of pyroptosis and TME in the occurrence and development of gynecological malignant tumors, so as to find more efficient and accurate biomarkers on the basis of pyroptosis which can screen patients in the early stage and promote the development of accurate treatment and immunotherapy. We hope this Research Topic provides new and personalized strategies for the treatment of gynecological malignant tumors to reduce the adverse consequences of gynecological malignancies in women.
We welcome submissions of Original Research, Reviews, Hypothesis and Theory, Opinions, and Clinical Trials, focusing on but not limited to the following topics:
1. Mechanisms of pyroptosis affecting the development of gynecologic malignant tumors through TME.
2. The relationship and interaction between TME composition and pyroptosis in gynecologic malignant tumors.
3. Immune cells or stromal cells in TME during the occurrence and development of gynecologic malignant tumors.
4. Screening for new prognosis markers related to pyroptosis in gynecologic malignant tumors.
5. Identification of potential immunotherapeutic targets for gynecological malignancies immunotherapy according to the heterogeneity of TME.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Gynecological malignancies are the second most common cancer in women all over the world, and their incidence tends to be higher among younger women. Although great progress has been made in the prevention and treatment of gynecological malignancies in recent years, there is still a lack of effective treatment in an advanced stage, which seriously threatens women's health. Pyroptosis, as programmed cell death, participates in tumor proliferation, invasion, and metastasis. In recent years, it has become a new hotspot in tumor research. Tumor cells colonized in normal tissues can form tumor microenvironment (TME) together with stromal cells, immune cells and their secretory factors, vascular endothelial cells, and extracellular matrix. These immune cells and related stromal components form an anti-tumor inflammatory microenvironment in the early stage of tumor colonization or growth, which hinders the occurrence and development of tumors. Further, exploring the role of pyroptosis and TME in the occurrence and development of gynecological malignancies will provide a new strategy for the treatment of gynecological malignancies.
This Research Topic focuses on the relationship between pyroptosis and TME, as well as their interaction in the progression of gynecological malignancies. The purpose is to clarify the biological mechanism of pyroptosis and TME in the occurrence and development of gynecological malignant tumors, so as to find more efficient and accurate biomarkers on the basis of pyroptosis which can screen patients in the early stage and promote the development of accurate treatment and immunotherapy. We hope this Research Topic provides new and personalized strategies for the treatment of gynecological malignant tumors to reduce the adverse consequences of gynecological malignancies in women.
We welcome submissions of Original Research, Reviews, Hypothesis and Theory, Opinions, and Clinical Trials, focusing on but not limited to the following topics:
1. Mechanisms of pyroptosis affecting the development of gynecologic malignant tumors through TME.
2. The relationship and interaction between TME composition and pyroptosis in gynecologic malignant tumors.
3. Immune cells or stromal cells in TME during the occurrence and development of gynecologic malignant tumors.
4. Screening for new prognosis markers related to pyroptosis in gynecologic malignant tumors.
5. Identification of potential immunotherapeutic targets for gynecological malignancies immunotherapy according to the heterogeneity of TME.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
