Hemostasis represents a physiological mechanism that ensures a balance between pro- and anti-coagulant factors. It is a dynamic and complex process evolving from fetal life through adulthood. Despite the recent advances and progress in neonatal hematology, neonatal hemostasis remains an obscure field. The hemostatic alterations in sick neonates, ranging from mild hemorrhage (bleeding from venipuncture sites) to severe and life-threatening or thrombotic events are still critical issues for neonatologists, often complicating various clinical conditions, especially in preterm neonates. Thus, a thorough comprehension of the developmental stage of hemostasis and the underlying pathophysiology is crucial for the appropriate evaluation of risk factors and the therapeutic management of hemostatic derangements in the neonatal population.
The goal of this Research Topic is to highlight recent advances focused on pathophysiology, diagnosis, and prediction of hemostatic derangements in sick neonates and also provide new insights into the management of specific clinical settings. Furthermore, we intend to fill gaps in knowledge of neonatal transfusion therapy and enforce the need for international collaboration to establish evidence-based guidelines.
We invite researchers to submit manuscripts of experimental and clinical research, systematic reviews or meta-analyses which cover, but are not limited to, the following topics:
• The use of more sensitive coagulation assays and new tools for the diagnosis of coagulation disorders
• New biomarkers for diagnosis and therapy monitoring of coagulation disorders in neonates
• Predictive scores for neonatal bleeding events
• Perinatal asphyxia and hemostatic derangements
• Hemostasis and inflammation: probable correlations and interactions
• Etiology, pathophysiology, clinical manifestations, diagnosis, and optimal management of critically ill neonates with disseminated intravascular coagulation
• Evaluation of the efficacy and monitoring of transfusion therapy with new coagulation assays.
Hemostasis represents a physiological mechanism that ensures a balance between pro- and anti-coagulant factors. It is a dynamic and complex process evolving from fetal life through adulthood. Despite the recent advances and progress in neonatal hematology, neonatal hemostasis remains an obscure field. The hemostatic alterations in sick neonates, ranging from mild hemorrhage (bleeding from venipuncture sites) to severe and life-threatening or thrombotic events are still critical issues for neonatologists, often complicating various clinical conditions, especially in preterm neonates. Thus, a thorough comprehension of the developmental stage of hemostasis and the underlying pathophysiology is crucial for the appropriate evaluation of risk factors and the therapeutic management of hemostatic derangements in the neonatal population.
The goal of this Research Topic is to highlight recent advances focused on pathophysiology, diagnosis, and prediction of hemostatic derangements in sick neonates and also provide new insights into the management of specific clinical settings. Furthermore, we intend to fill gaps in knowledge of neonatal transfusion therapy and enforce the need for international collaboration to establish evidence-based guidelines.
We invite researchers to submit manuscripts of experimental and clinical research, systematic reviews or meta-analyses which cover, but are not limited to, the following topics:
• The use of more sensitive coagulation assays and new tools for the diagnosis of coagulation disorders
• New biomarkers for diagnosis and therapy monitoring of coagulation disorders in neonates
• Predictive scores for neonatal bleeding events
• Perinatal asphyxia and hemostatic derangements
• Hemostasis and inflammation: probable correlations and interactions
• Etiology, pathophysiology, clinical manifestations, diagnosis, and optimal management of critically ill neonates with disseminated intravascular coagulation
• Evaluation of the efficacy and monitoring of transfusion therapy with new coagulation assays.
