Anticancer drugs' specificity and precise mechanism are crucial in reducing the severity of side effects associated with the drugs' use. However, due to the similarity between cancer cells and non-cancerous (normal) cells in our body, anticancer agents are generally toxic to normal cells that can cause numerous side effects, some of which are life-threatening. Those adverse effects may require that the drug dosages be reduced, or the drug regimen be changed to make the drugs tolerable to the patients. In the last decade, many studies have been performed to understand cancer's response by considering the individual aberrant genetic background, which yields essential information for precision medicine. Furthermore, exploring the coping mechanisms of the malignancy after exposure to drug treatments provides hints about compensatory strategies resulting in drug resistance and how to tackle the "Achilles heel" of cancer progression with a recently developed idea on precision medicine approach.
This Research Topic will include Original Research, Reviews, and Perspectives covering the latest development of molecular pharmacology in the precision medicine era. We aim to bring leading researchers together to exchange and share their recent findings in molecular pharmacology and precision medicine for cancer treatment. We believe that this platform could provide a glimpse of the future of our discipline to understanding cancer's response with the latest mechanistic insights and further consider the individual aberrant genetic background to tackling drug resistance by using targeted therapy and immunotherapy combination approach.
Anticancer drugs' specificity and precise mechanism are crucial in reducing the severity of side effects associated with the drugs' use. However, due to the similarity between cancer cells and non-cancerous (normal) cells in our body, anticancer agents are generally toxic to normal cells that can cause numerous side effects, some of which are life-threatening. Those adverse effects may require that the drug dosages be reduced, or the drug regimen be changed to make the drugs tolerable to the patients. In the last decade, many studies have been performed to understand cancer's response by considering the individual aberrant genetic background, which yields essential information for precision medicine. Furthermore, exploring the coping mechanisms of the malignancy after exposure to drug treatments provides hints about compensatory strategies resulting in drug resistance and how to tackle the "Achilles heel" of cancer progression with a recently developed idea on precision medicine approach.
This Research Topic will include Original Research, Reviews, and Perspectives covering the latest development of molecular pharmacology in the precision medicine era. We aim to bring leading researchers together to exchange and share their recent findings in molecular pharmacology and precision medicine for cancer treatment. We believe that this platform could provide a glimpse of the future of our discipline to understanding cancer's response with the latest mechanistic insights and further consider the individual aberrant genetic background to tackling drug resistance by using targeted therapy and immunotherapy combination approach.
