Optical imaging has developed rapidly in recent years owing to its high sensitivity, strong specificity, and fast imaging speed. Optical microscopy, including confocal microscopy (CM), light-sheet microscopy (LSM), multi-photon microscopy (MPM), super-resolution microscopy (SRM) and photoacoustic microscopy (PAM), etc, provides nanometer to micrometer spatial resolution and microsecond temporal resolution, which allows the studies of neuroscience and brain disease at the cellular or molecular level. Optical tomography on the other hand, including bioluminescence tomography (BLT), fluorescence molecular tomography (FMT), x-ray luminescence tomography (XLT), Cerenkov luminescence tomography (CLT), photoacoustic tomography (PAT), diffusion optical tomography (DOT), etc, achieves the penetration depth of a few centimeters, making it possible to study the neuroscience and brain disease in vivo. These optical imaging technologies have enormously expanded the research of neuroscience and brain disease across multiple scales, from the molecular and cellular level to the whole brain level.
The objective of this Research Topic is to highlight the cutting-edge methods (e.g., methodological improvements, new algorithms, validation studies, etc.) and novel applications (e.g., biological applications, pre-clinical applications, clinical applications, etc.) of two-dimensional (2D) and three-dimensional (3D) optical imaging technologies used to carry out various studies of neuroscience and brain disease. The submissions can cover cutting-edge imaging systems, imaging methods, and imaging probes, as well as novel biological/pre-clinical/clinical studies or applications.
Topics of interest include, but are not limited to, the following:
1. Cutting-edge optical imaging methods for neuroscience and brain disease:
1.1 Fluorescence microscopy: confocal microscopy, light-sheet microscopy, multi-photon microscopy, super-resolution microscopy
1.2 Fluorescence tomography: bioluminescence tomography, fluorescence molecular tomography, x-ray luminescence tomography, Cerenkov luminescence tomography
1.3 Photoacoustic microscopy: optical-resolution photoacoustic microscopy, acoustic-resolution photoacoustic microscopy, high-speed photoacoustic microscopy
1.4 Photoacoustic tomography: novel instruments or imaging methods
2. Novel biological/pre-clinical/clinical applications for neuroscience and brain disease using optical imaging techniques:
2.1 Optical imaging of the microenvironment of various brain tumors
2.2 Monitoring of the neural circuits or activities
2.3 Optical imaging of the molecular properties of neurodegenerative diseases
2.4 Functional imaging of brain activity or disorder
Optical imaging has developed rapidly in recent years owing to its high sensitivity, strong specificity, and fast imaging speed. Optical microscopy, including confocal microscopy (CM), light-sheet microscopy (LSM), multi-photon microscopy (MPM), super-resolution microscopy (SRM) and photoacoustic microscopy (PAM), etc, provides nanometer to micrometer spatial resolution and microsecond temporal resolution, which allows the studies of neuroscience and brain disease at the cellular or molecular level. Optical tomography on the other hand, including bioluminescence tomography (BLT), fluorescence molecular tomography (FMT), x-ray luminescence tomography (XLT), Cerenkov luminescence tomography (CLT), photoacoustic tomography (PAT), diffusion optical tomography (DOT), etc, achieves the penetration depth of a few centimeters, making it possible to study the neuroscience and brain disease in vivo. These optical imaging technologies have enormously expanded the research of neuroscience and brain disease across multiple scales, from the molecular and cellular level to the whole brain level.
The objective of this Research Topic is to highlight the cutting-edge methods (e.g., methodological improvements, new algorithms, validation studies, etc.) and novel applications (e.g., biological applications, pre-clinical applications, clinical applications, etc.) of two-dimensional (2D) and three-dimensional (3D) optical imaging technologies used to carry out various studies of neuroscience and brain disease. The submissions can cover cutting-edge imaging systems, imaging methods, and imaging probes, as well as novel biological/pre-clinical/clinical studies or applications.
Topics of interest include, but are not limited to, the following:
1. Cutting-edge optical imaging methods for neuroscience and brain disease:
1.1 Fluorescence microscopy: confocal microscopy, light-sheet microscopy, multi-photon microscopy, super-resolution microscopy
1.2 Fluorescence tomography: bioluminescence tomography, fluorescence molecular tomography, x-ray luminescence tomography, Cerenkov luminescence tomography
1.3 Photoacoustic microscopy: optical-resolution photoacoustic microscopy, acoustic-resolution photoacoustic microscopy, high-speed photoacoustic microscopy
1.4 Photoacoustic tomography: novel instruments or imaging methods
2. Novel biological/pre-clinical/clinical applications for neuroscience and brain disease using optical imaging techniques:
2.1 Optical imaging of the microenvironment of various brain tumors
2.2 Monitoring of the neural circuits or activities
2.3 Optical imaging of the molecular properties of neurodegenerative diseases
2.4 Functional imaging of brain activity or disorder