The One Health concept, introduced at the beginning of the 2000s, is a worldwide strategy for promoting multidisciplinary partnerships and information in all facets of health care sciences, perceiving the interrelationship between humans, animals, plants, and their common environment. Recent advances in DNA sequencing technology and computational biology have revolutionized the field of the microbiome. Information surrounding uncultured microorganisms provides a comprehensive analysis of the relationships between an animal, the environment, and human's microbiota, including various disease correlations. In this Research Topic, we are interested in exploring how environmental stress effects bacterial communities, and how those changes relate to human health and pathobiont transmission in experimental and big data analysis.
Antibiotic resistance is widely recognized as a critical one health issue. Vancomycin resistant Enterococci and Clostridium difficile are the most recognized examples which transmit from the environment to the human body. Previously, it was considered that C. difficile was primarily a hospital-acquired infection, however, whole-genome sequencing results suggest that the majority of hospital C. difficile infection (CDI) cases originate from sources/reservoirs outside of hospitals that play a significant role in its transmission. Many of these resistance determinants originate in antibiotic-producing organisms in the environment. The modern environmental resistome is under selective pressure from human activities, such as agriculture, which may influence the composition of the local resistome and lead to their gene transfer events. A healthy donor’s stool restores normal microflora in the gut via fecal microbiota transplantation (FMT), which has become a more readily available treatment option for CDI and gut dysbiosis conditions such as inflammatory bowel disease and ulcerative colitis. However, because of the complexity of microbiota and hosts interactions, this treatment is still controversial. Based on the one health concept, we are interested in determining how environmental stress impacts the resistome and pathobionts and how those pathobionts disrupt normal microbiota to cause diseases.
In this Research Topic, manuscripts related to keywords below will be highly appreciated.
Key words of this Research Topic are:
1. Eco Epidemiology
2. Human Microbiome
3. Biotic-Abiotic Interaction with Infection
4. Pathobiont
5. Dysbiosis
6. One Health
These keywords are in relation to microbial genomics and ecology. The guest editors hope to include studies that are conducting experimental confirmation of the hypothesis inferred from big data analysis as well as bioinformatics research using high throughput DNA sequencers.
The One Health concept, introduced at the beginning of the 2000s, is a worldwide strategy for promoting multidisciplinary partnerships and information in all facets of health care sciences, perceiving the interrelationship between humans, animals, plants, and their common environment. Recent advances in DNA sequencing technology and computational biology have revolutionized the field of the microbiome. Information surrounding uncultured microorganisms provides a comprehensive analysis of the relationships between an animal, the environment, and human's microbiota, including various disease correlations. In this Research Topic, we are interested in exploring how environmental stress effects bacterial communities, and how those changes relate to human health and pathobiont transmission in experimental and big data analysis.
Antibiotic resistance is widely recognized as a critical one health issue. Vancomycin resistant Enterococci and Clostridium difficile are the most recognized examples which transmit from the environment to the human body. Previously, it was considered that C. difficile was primarily a hospital-acquired infection, however, whole-genome sequencing results suggest that the majority of hospital C. difficile infection (CDI) cases originate from sources/reservoirs outside of hospitals that play a significant role in its transmission. Many of these resistance determinants originate in antibiotic-producing organisms in the environment. The modern environmental resistome is under selective pressure from human activities, such as agriculture, which may influence the composition of the local resistome and lead to their gene transfer events. A healthy donor’s stool restores normal microflora in the gut via fecal microbiota transplantation (FMT), which has become a more readily available treatment option for CDI and gut dysbiosis conditions such as inflammatory bowel disease and ulcerative colitis. However, because of the complexity of microbiota and hosts interactions, this treatment is still controversial. Based on the one health concept, we are interested in determining how environmental stress impacts the resistome and pathobionts and how those pathobionts disrupt normal microbiota to cause diseases.
In this Research Topic, manuscripts related to keywords below will be highly appreciated.
Key words of this Research Topic are:
1. Eco Epidemiology
2. Human Microbiome
3. Biotic-Abiotic Interaction with Infection
4. Pathobiont
5. Dysbiosis
6. One Health
These keywords are in relation to microbial genomics and ecology. The guest editors hope to include studies that are conducting experimental confirmation of the hypothesis inferred from big data analysis as well as bioinformatics research using high throughput DNA sequencers.
