Endometrial cancer (EC) is the most frequent gynecological malignancy in the developed world. Optimal treatment of EC depends on early diagnosis and pre-operative stratification to appropriately select the extent of surgery and to plan further therapeutic approaches. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid non-invasive methods available, and patient stratification is based on histopathology and surgical findings.
There is a great need for a prognostic test to stratify pre-operatively EC patients with high risk of progression and in need of radical surgery together with adjuvant chemo/radio therapy and distinguish them from EC patients with good prognosis, who do not need further treatment beside primary surgery. There is also need for non-invasive diagnostics as screening test for early diagnosis of cancer followed by tailored treatment. This Research Topic aims to gather the expanding knowledge on omics profiling, multiomics and studies on molecular mechanisms that provide new insights into pathophysiology of EC with important impacts on future directions for diagnosing, predicting prognosis and response to treatment.
The scope of this Research Topic is translational research focusing on improving current diagnosis/prognosis and treatment of EC. High quality Original Research articles, Systematic Reviews, Narrative Reviews, Mini Review, and Brief Research Reports that describe different aspects of translational research, with particular emphasis on omics profiling and multi-omics in tissues and physiological fluids, but also studies on molecular mechanisms that underlie the pathophysiology are welcome.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Endometrial cancer (EC) is the most frequent gynecological malignancy in the developed world. Optimal treatment of EC depends on early diagnosis and pre-operative stratification to appropriately select the extent of surgery and to plan further therapeutic approaches. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid non-invasive methods available, and patient stratification is based on histopathology and surgical findings.
There is a great need for a prognostic test to stratify pre-operatively EC patients with high risk of progression and in need of radical surgery together with adjuvant chemo/radio therapy and distinguish them from EC patients with good prognosis, who do not need further treatment beside primary surgery. There is also need for non-invasive diagnostics as screening test for early diagnosis of cancer followed by tailored treatment. This Research Topic aims to gather the expanding knowledge on omics profiling, multiomics and studies on molecular mechanisms that provide new insights into pathophysiology of EC with important impacts on future directions for diagnosing, predicting prognosis and response to treatment.
The scope of this Research Topic is translational research focusing on improving current diagnosis/prognosis and treatment of EC. High quality Original Research articles, Systematic Reviews, Narrative Reviews, Mini Review, and Brief Research Reports that describe different aspects of translational research, with particular emphasis on omics profiling and multi-omics in tissues and physiological fluids, but also studies on molecular mechanisms that underlie the pathophysiology are welcome.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.