Parvoviruses are small nonenveloped icosahedral viruses with linear single-stranded DNA genomes of 4-6 kb with terminal repeats forming hairpin structures at both ends. The family Parvoviridae comprises so far three subfamilies; Parvovirinae, Densovirinae, and Hamaparvovirinae, with virus members infecting either vertebrate or invertebrate hosts, or both, respectively. Parvovirus replication is highly dependent on host cell factors including DNA polymerases. Their replication mostly takes place in actively dividing cells and sometimes also in quiescent cells. Parvoviruses cause from subclinical to deadly infections and often persist in the host with unknown consequences. Some parvoviruses are used for oncolytic purposes, like H-1PV and MVM, and others as vectors for gene therapy, like AAVs. The most widely known parvovirus pathogens of humans are B19V and human bocavirus 1 (HBoV1), and of animals, the canine, mink, bovine, and porcine parvoviruses (CPV, AMDV, BPV, PPV), for which vaccines are available, and the mouse parvovirus (MVM), which has been most widely studied. Many densoviruses are further highly pathogenic for insects and can be used in biocontrol.
This Research Topic will gather recent progress in all forms of parvovirus research, from basic to applied research. Submissions will focus on the recent advances in parvovirus research across the entire spectrum of molecular, clinical, and applied parvovirology, addressing emerging novel parvoviruses, viral structures, virus-cell interactions, replication cycle, epidemiology, evolution, diagnostics, pathogenesis, persistence, and biotechnological applications, such as biocontrol, antivirals, vaccines, gene therapy and oncolytic parvoviruses.
This Research Topic will accept different types of articles, including Original Research, Review, Opinion, and Mini Review.
COI Statement: Jianming Qiu is a co-founder and advisor of Carbon Biosciences, Inc., Cambridge, MA, USA.
Parvoviruses are small nonenveloped icosahedral viruses with linear single-stranded DNA genomes of 4-6 kb with terminal repeats forming hairpin structures at both ends. The family Parvoviridae comprises so far three subfamilies; Parvovirinae, Densovirinae, and Hamaparvovirinae, with virus members infecting either vertebrate or invertebrate hosts, or both, respectively. Parvovirus replication is highly dependent on host cell factors including DNA polymerases. Their replication mostly takes place in actively dividing cells and sometimes also in quiescent cells. Parvoviruses cause from subclinical to deadly infections and often persist in the host with unknown consequences. Some parvoviruses are used for oncolytic purposes, like H-1PV and MVM, and others as vectors for gene therapy, like AAVs. The most widely known parvovirus pathogens of humans are B19V and human bocavirus 1 (HBoV1), and of animals, the canine, mink, bovine, and porcine parvoviruses (CPV, AMDV, BPV, PPV), for which vaccines are available, and the mouse parvovirus (MVM), which has been most widely studied. Many densoviruses are further highly pathogenic for insects and can be used in biocontrol.
This Research Topic will gather recent progress in all forms of parvovirus research, from basic to applied research. Submissions will focus on the recent advances in parvovirus research across the entire spectrum of molecular, clinical, and applied parvovirology, addressing emerging novel parvoviruses, viral structures, virus-cell interactions, replication cycle, epidemiology, evolution, diagnostics, pathogenesis, persistence, and biotechnological applications, such as biocontrol, antivirals, vaccines, gene therapy and oncolytic parvoviruses.
This Research Topic will accept different types of articles, including Original Research, Review, Opinion, and Mini Review.
COI Statement: Jianming Qiu is a co-founder and advisor of Carbon Biosciences, Inc., Cambridge, MA, USA.