Primary cilia coordinate transduction of all major signaling pathways including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), and morphogens (e.g. Hedgehog, WNT, planar cell polarity, fibroblast growth factor, and bone morphogenetic protein). Collectively, these signaling pathways mediate key aspects of embryonic development including patterning, organ morphogenesis, and cellular differentiation, migration, and proliferation. Notably, many of the same signaling modules are also required for proper cilia morphogenesis and function.
Perturbation of signaling pathways orchestrated by primary cilia as well as defects in cilia structure or function result in developmental disorders and birth defects, which contribute to early mortality. In addition, recent work suggests that signaling pathways in the primary cilia could be the responders against the environmental stimuli (i.e. teratogens) to fine tune the signaling output. Therefore, comprehensive understanding of mechanisms by which ciliary signaling influences distinct developmental programs is critical to better understand etiology of developmental disorders and birth defects.
The goal of this Research topic is to showcase recent and novel work that will advance our understanding of mechanisms by which primary cilia coordinate signaling networks during normal development and how disruption of cilia-based signaling pathways manifests in developmental disorders and birth defects.
We are interested in original research, mini review, review, and methods articles that describe the roles of cilia-dependent signaling pathways in normal development or disease. New perspectives regarding the etiology of birth defects, such as genetic mutations of morphogen signaling components, are also welcome.
Areas to be covered in this Research topic may include, but are not limited to:
• Novel cellular and developmental mechanisms of morphogen signaling in vitro and in vivo.
• Mechanistic studies of morphogen, GPCR, and RTK signaling via primary cilia during development.
• Cilia-dependent signaling mechanisms of patterning, tissue specification, organ development, and cellular differentiation, migration, and proliferation.
• Disease models of ciliopathies and morphogen-dependent birth defects in vertebrates and invertebrates.
• Environment-morphogen signaling interaction in birth defects models.
• Experimental approaches to manipulate and analyze cilia-based signaling.
• Signaling-dependent cilia remodeling and morphogenesis.
Primary cilia coordinate transduction of all major signaling pathways including G protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), and morphogens (e.g. Hedgehog, WNT, planar cell polarity, fibroblast growth factor, and bone morphogenetic protein). Collectively, these signaling pathways mediate key aspects of embryonic development including patterning, organ morphogenesis, and cellular differentiation, migration, and proliferation. Notably, many of the same signaling modules are also required for proper cilia morphogenesis and function.
Perturbation of signaling pathways orchestrated by primary cilia as well as defects in cilia structure or function result in developmental disorders and birth defects, which contribute to early mortality. In addition, recent work suggests that signaling pathways in the primary cilia could be the responders against the environmental stimuli (i.e. teratogens) to fine tune the signaling output. Therefore, comprehensive understanding of mechanisms by which ciliary signaling influences distinct developmental programs is critical to better understand etiology of developmental disorders and birth defects.
The goal of this Research topic is to showcase recent and novel work that will advance our understanding of mechanisms by which primary cilia coordinate signaling networks during normal development and how disruption of cilia-based signaling pathways manifests in developmental disorders and birth defects.
We are interested in original research, mini review, review, and methods articles that describe the roles of cilia-dependent signaling pathways in normal development or disease. New perspectives regarding the etiology of birth defects, such as genetic mutations of morphogen signaling components, are also welcome.
Areas to be covered in this Research topic may include, but are not limited to:
• Novel cellular and developmental mechanisms of morphogen signaling in vitro and in vivo.
• Mechanistic studies of morphogen, GPCR, and RTK signaling via primary cilia during development.
• Cilia-dependent signaling mechanisms of patterning, tissue specification, organ development, and cellular differentiation, migration, and proliferation.
• Disease models of ciliopathies and morphogen-dependent birth defects in vertebrates and invertebrates.
• Environment-morphogen signaling interaction in birth defects models.
• Experimental approaches to manipulate and analyze cilia-based signaling.
• Signaling-dependent cilia remodeling and morphogenesis.
