Pulmonary vein isolation (PVI), albeit an established recommended catheter ablation approach for atrial fibrillation (AF), yields suboptimal clinical outcomes in the setting of persistent AF warranting elucidation of underlying mechanisms. Therefore, exploring the maintenance mechanism of the extra-pulmonary vein (PV) is the basis for the successful ablation of persistent AF. To this end, the driving of AF is a novel mechanistic factor affecting the rest of the atria during persistent AF. Some anatomical structures of atria have been found to engage in driver formation. Thus, it is necessary to study the ablation strategy of driver ablation and substrate modification. Although some previous studies failed to show therapeutic benefits of PVI plus driver ablation over PVI alone, with the help of big data analysis, the mathematical driver model is expected to uncover the mechanisms of persistent AF and reinvent novel mapping methods.
In this Research Topic, we would like to create a forum for current advances on ablation strategy of persistent AF, method or technologies of driver mapping and ablation, studies of driver mechanism in special populations with persistent AF and clinical trial of AF management strategies.
We welcome Original Research, Systematic Review, state-of-the-art Review and challenging/informative case series in ablation strategy of atrial fibrillation and method or technologies of driver/rotor mapping.
Potential paper themes include:
1) Driver mapping method and technologies in persistent atrial fibrillation (AF).
2) Ablation strategy of persistent AF, such as driver ablation and ablation for extra-PV maintenance substrate.
3) The clinical translational application of the mathematical analysis method or model of the driver/rotor.
4) The relationship between anatomical structures of the atrium and the formation of the driver.
5) Big data analysis on AF ablation strategies.
6) Ablation strategies for AF patients with organic heart disease or other special diseases.
Pulmonary vein isolation (PVI), albeit an established recommended catheter ablation approach for atrial fibrillation (AF), yields suboptimal clinical outcomes in the setting of persistent AF warranting elucidation of underlying mechanisms. Therefore, exploring the maintenance mechanism of the extra-pulmonary vein (PV) is the basis for the successful ablation of persistent AF. To this end, the driving of AF is a novel mechanistic factor affecting the rest of the atria during persistent AF. Some anatomical structures of atria have been found to engage in driver formation. Thus, it is necessary to study the ablation strategy of driver ablation and substrate modification. Although some previous studies failed to show therapeutic benefits of PVI plus driver ablation over PVI alone, with the help of big data analysis, the mathematical driver model is expected to uncover the mechanisms of persistent AF and reinvent novel mapping methods.
In this Research Topic, we would like to create a forum for current advances on ablation strategy of persistent AF, method or technologies of driver mapping and ablation, studies of driver mechanism in special populations with persistent AF and clinical trial of AF management strategies.
We welcome Original Research, Systematic Review, state-of-the-art Review and challenging/informative case series in ablation strategy of atrial fibrillation and method or technologies of driver/rotor mapping.
Potential paper themes include:
1) Driver mapping method and technologies in persistent atrial fibrillation (AF).
2) Ablation strategy of persistent AF, such as driver ablation and ablation for extra-PV maintenance substrate.
3) The clinical translational application of the mathematical analysis method or model of the driver/rotor.
4) The relationship between anatomical structures of the atrium and the formation of the driver.
5) Big data analysis on AF ablation strategies.
6) Ablation strategies for AF patients with organic heart disease or other special diseases.