Prostate cancer is one of the most common genitourinary malignancies with a high mortality and poor prognosis. Studies have shown that androgen receptor signaling has a significant role in the development and progression of prostate cancer by binding to androgen response elements resulting in the transcription of target genes and promoting prostate cancer tumorigenesis. Targeted therapeutic approaches include to control tumor progression include radical prostatectomy, radiotherapy and androgen deprivation therapy (ADT), however prostate cancer can also reoccur after intervention.
Epigenetic changes including modifications of DNA and histones as well as chromatin looping, chromatin structure and chromosomal interactions are strongly associated with prostate cancer tumorigenesis. Molecular pathways which regulate epigenetic changes shall also be addressed which include altered expression of non-coding RNAs, bypass mechanisms of androgen receptor signaling, mutation load, epigenetic modulators. This shall provide novel information for therapy resistance of prostate cancer.
Endogenously synthesized microRNAs are a class of small non-coding regulatory RNAs that are well preserved among the species. They have critical roles on gene regulations and one of the major components of the epigenome. Expressions of most of human genes are thought to be regulated by microRNAs. MicroRNAs interfere with various cellular pathways including proliferation and differentiation through affecting their targets’ expression in mRNA level and also in post-transcription level. MicroRNAs, which might have tumor suppressor or oncogenic potential, have been demonstrated to be able to distinguish different states of prostate cancer. In prostate cancer tissues as compared to benign prostatic hyperplasia samples, various differential expressions of noncoding RNAs including microRNAs have been demonstrated. In addition to tumor tissues, body fluids including prostatic secretions and serum samples also presented differential expressions of non-coding RNAs present in exosomes. Exosomes are small vesicles about 100 nm in size secreted from the cells. Exosomes are thought to be the new way of communication of the cells long distance. It is known that small RNAs including microRNAs can be found in exosomes. These small RNAs are secreted from the cells via exosomes.
The aim of this Research Topic is to provide updated information and novel contributions focusing on how epigenetic changes influence prostate cancer tumorigenesis. We invite authors to submit Original Research Articles and Review Articles.
Topics of interest include:
-Epigenetic changes that include modifications of DNA and histones as well as chromatin looping, chromatin structure and chromosomal interactions associated with prostate cancer tumorigenesis.
-Molecular pathways which regulate altered expression of non-coding RNAs, bypass mechanisms of androgen signaling, mutation load and epigenetic modulators.
-Determination of epigenetic changes including differential expression of non-coding RNAs in tumor tissues and all biological secretions inclusive of exosomes.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Prostate cancer is one of the most common genitourinary malignancies with a high mortality and poor prognosis. Studies have shown that androgen receptor signaling has a significant role in the development and progression of prostate cancer by binding to androgen response elements resulting in the transcription of target genes and promoting prostate cancer tumorigenesis. Targeted therapeutic approaches include to control tumor progression include radical prostatectomy, radiotherapy and androgen deprivation therapy (ADT), however prostate cancer can also reoccur after intervention.
Epigenetic changes including modifications of DNA and histones as well as chromatin looping, chromatin structure and chromosomal interactions are strongly associated with prostate cancer tumorigenesis. Molecular pathways which regulate epigenetic changes shall also be addressed which include altered expression of non-coding RNAs, bypass mechanisms of androgen receptor signaling, mutation load, epigenetic modulators. This shall provide novel information for therapy resistance of prostate cancer.
Endogenously synthesized microRNAs are a class of small non-coding regulatory RNAs that are well preserved among the species. They have critical roles on gene regulations and one of the major components of the epigenome. Expressions of most of human genes are thought to be regulated by microRNAs. MicroRNAs interfere with various cellular pathways including proliferation and differentiation through affecting their targets’ expression in mRNA level and also in post-transcription level. MicroRNAs, which might have tumor suppressor or oncogenic potential, have been demonstrated to be able to distinguish different states of prostate cancer. In prostate cancer tissues as compared to benign prostatic hyperplasia samples, various differential expressions of noncoding RNAs including microRNAs have been demonstrated. In addition to tumor tissues, body fluids including prostatic secretions and serum samples also presented differential expressions of non-coding RNAs present in exosomes. Exosomes are small vesicles about 100 nm in size secreted from the cells. Exosomes are thought to be the new way of communication of the cells long distance. It is known that small RNAs including microRNAs can be found in exosomes. These small RNAs are secreted from the cells via exosomes.
The aim of this Research Topic is to provide updated information and novel contributions focusing on how epigenetic changes influence prostate cancer tumorigenesis. We invite authors to submit Original Research Articles and Review Articles.
Topics of interest include:
-Epigenetic changes that include modifications of DNA and histones as well as chromatin looping, chromatin structure and chromosomal interactions associated with prostate cancer tumorigenesis.
-Molecular pathways which regulate altered expression of non-coding RNAs, bypass mechanisms of androgen signaling, mutation load and epigenetic modulators.
-Determination of epigenetic changes including differential expression of non-coding RNAs in tumor tissues and all biological secretions inclusive of exosomes.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
