The immunological characteristics of tissues and organs (such as skin, liver, intestine, lung, kidney, uterus, etc.) are very different. These tissues and organs may contain specific or unique immune cell subgroups and functional molecules due to their unique structure, physiological function, and tissue microenvironment, which form regional immune characteristics. For example, the tissue-resident immune cells in the liver, small intestine, and skin play an important role in anti-infection immunity; the tissue-resident immune cells in the uterus play a key role in the establishment and maintenance of pregnancy. When these organs are transplanted, how will the original immune characteristics change in the grafts? Will they be regularly replaced and rebuilt by recipient immune cells? How do related changes affect the function of the graft? In addition, This regional immune characteristic may be closely related to the occurrence and development of all-rejection. However, so far there is no journal or special issue to specifically discuss the related issues. Therefore, it is necessary to launch a Research Topic to highlight the research results on the regional immune characteristics of tissues and organs graft. This is of great significance for revealing the internal relationship between regional immune characteristics and transplant, improving graft function, and finding new immunotherapy targets.
This Research Topic is to provide a forum for exploring the interactions between transplantation and regional immune characteristics of tissues and organs grafts (e.g., skin, liver, intestine, lung, kidney, uterus, etc.) so that people can better understand the changing rules and influencing factors of the regional immune characteristics of the grafts after transplantation, and provide a theoretical basis for improving the function of the grafts.
Here, we welcome manuscripts from, but not limited to, the following subtopics:
• The characteristics and attributes of specific immune cell subsets in tissues and organs grafts (e.g., skin, liver, intestine, lung, kidney, uterus, etc.)
• Cellular and molecular regulatory network of regional immune characteristics
• Changes and influencing factors of immune characteristics in different grafts after transplantation
• The influence of graft immune characteristics on the occurrence and development of immune rejection
• Comparative study of the regional immune characteristics between different grafts to find new strategies for immune tolerance
• Strategies to rebuild the immune microenvironment of the graft after transplantation to improve the function of the graft
The immunological characteristics of tissues and organs (such as skin, liver, intestine, lung, kidney, uterus, etc.) are very different. These tissues and organs may contain specific or unique immune cell subgroups and functional molecules due to their unique structure, physiological function, and tissue microenvironment, which form regional immune characteristics. For example, the tissue-resident immune cells in the liver, small intestine, and skin play an important role in anti-infection immunity; the tissue-resident immune cells in the uterus play a key role in the establishment and maintenance of pregnancy. When these organs are transplanted, how will the original immune characteristics change in the grafts? Will they be regularly replaced and rebuilt by recipient immune cells? How do related changes affect the function of the graft? In addition, This regional immune characteristic may be closely related to the occurrence and development of all-rejection. However, so far there is no journal or special issue to specifically discuss the related issues. Therefore, it is necessary to launch a Research Topic to highlight the research results on the regional immune characteristics of tissues and organs graft. This is of great significance for revealing the internal relationship between regional immune characteristics and transplant, improving graft function, and finding new immunotherapy targets.
This Research Topic is to provide a forum for exploring the interactions between transplantation and regional immune characteristics of tissues and organs grafts (e.g., skin, liver, intestine, lung, kidney, uterus, etc.) so that people can better understand the changing rules and influencing factors of the regional immune characteristics of the grafts after transplantation, and provide a theoretical basis for improving the function of the grafts.
Here, we welcome manuscripts from, but not limited to, the following subtopics:
• The characteristics and attributes of specific immune cell subsets in tissues and organs grafts (e.g., skin, liver, intestine, lung, kidney, uterus, etc.)
• Cellular and molecular regulatory network of regional immune characteristics
• Changes and influencing factors of immune characteristics in different grafts after transplantation
• The influence of graft immune characteristics on the occurrence and development of immune rejection
• Comparative study of the regional immune characteristics between different grafts to find new strategies for immune tolerance
• Strategies to rebuild the immune microenvironment of the graft after transplantation to improve the function of the graft
