Liver cancer is one of the most lethal cancers worldwide. Dysregulation of metabolism, both intrinsic and extrinsic to the liver, is known to contribute to the severe lethality of liver cancer, by enhancing liver carcinogenesis. Thus, identification of novel pathophysiologic mechanisms and associated targets in liver cancer and better characterization of already-known mechanisms and targets present exciting, emerging opportunities for diagnosis, treatment, and possibly even prevention of such cancer. Accordingly, for this Research Topic, we invite the submission of original research articles, review articles, as well as short communications which describe how cutting-edge discoveries about liver cancer metabolism and associated pathophysiology are leading to innovative ways to diagnose and combat liver cancer.
We welcome submissions related to the following sub-topics:
• Physiology of metabolic phenotypes in liver cancers
• Metabolism-mediated mechanisms of resistance to chemotherapy in liver cancers
• Metabolism-mediated mechanisms of cancer associated fibroblast promotion of liver cancers
• Metabolism-mediated mechanisms of the immunobiology of liver cancers
• Therapeutic targeting of metabolism in liver cancers
Liver cancer is one of the most lethal cancers worldwide. Dysregulation of metabolism, both intrinsic and extrinsic to the liver, is known to contribute to the severe lethality of liver cancer, by enhancing liver carcinogenesis. Thus, identification of novel pathophysiologic mechanisms and associated targets in liver cancer and better characterization of already-known mechanisms and targets present exciting, emerging opportunities for diagnosis, treatment, and possibly even prevention of such cancer. Accordingly, for this Research Topic, we invite the submission of original research articles, review articles, as well as short communications which describe how cutting-edge discoveries about liver cancer metabolism and associated pathophysiology are leading to innovative ways to diagnose and combat liver cancer.
We welcome submissions related to the following sub-topics:
• Physiology of metabolic phenotypes in liver cancers
• Metabolism-mediated mechanisms of resistance to chemotherapy in liver cancers
• Metabolism-mediated mechanisms of cancer associated fibroblast promotion of liver cancers
• Metabolism-mediated mechanisms of the immunobiology of liver cancers
• Therapeutic targeting of metabolism in liver cancers
