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Multiple facets of H+-pyrophosphatase and related enzymes

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Pyrophosphate (PPi) is generated in biosynthetic reactions such as the synthesis of UDP-glucose, the substrate for glycogen synthesis in animals and cellulose in plants. Other anabolic reactions such as polymerization of DNA, RNA and amino acid activation for protein synthesis also release PPi. In plants, ...

Pyrophosphate (PPi) is generated in biosynthetic reactions such as the synthesis of UDP-glucose, the substrate for glycogen synthesis in animals and cellulose in plants. Other anabolic reactions such as polymerization of DNA, RNA and amino acid activation for protein synthesis also release PPi. In plants, H+-translocating pyrophosphatases (H+-PPases) catalyze a coupled reaction of PPi hydrolysis and active proton transport across membranes. As the first role, PPi hydrolysis is important to promote anabolic biochemical reactions. PPi is hydrolyzed and its adequate concentrations within the different cellular compartments are maintained by H+-PPases and other organelle or cytosol-localized soluble type pyrophosphatases. As a second role, H+-PPase acidifies vacuolar lumen together with the vacuolar H+-ATPase. This role is important to energize the active transport of nutrients and ions across the vacuolar membrane and also to provide acidic conditions essential for enzymatic activities in the vacuole. While the biochemical properties of these two key enzymes (H+-PPase and H+-ATPase) have been dissected in previous reports, our knowledge about their contribution to plant growth and development in vivo under different environments and at different developmental stages and organs is fragmentary.
Therefore, it is valuable to overview recent progress and concepts on the relationship between PPi, H+-PPase, soluble-type pyrophosphatase, and vacuolar H+-ATPase. The Research Topic “Multiple facets of H+-pyrophosphatase and related enzymes” aims to shed light not only on the individual and distinct properties of each of the above enzymes, but also on their cooperative roles in vivo at organismal, organ, tissue, cell and organelle levels. We hope this research topic will also represent a platform to communicate and discuss the underlying mechanisms and principles by which these proton pumps contribute to plant development and adaptive processes. We welcome articles that provide insights into but not limited to the following aspects: - Biochemistry. - Molecular Biology. – Physiology. - Electrophysiology. - Stress-response and resistance. - Cell Biology. - Development. Therefore, this Research Topic aims to collate world-class submissions including Original Research, Reviews, Mini Reviews, Methods, commentaries, and Perspective and Opinion that communicate breakthroughs about the above enzymes not only in model organisms, but in a wide range of plant species.


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