Stem cell treatment is a curative treatment option for many hematological malignancies and cord blood transplantation (CBT) represents an alternative source of hematopoietic stem cells for patients who lack a suitable related or unrelated donor. CBT is associated with lower rates of chronic graft-versus-host disease (cGVHD), and relapse; however a low stem cell content in the graft results in slower immune reconstitution, higher risk of graft failure, severe infections, and transplant-related mortality (TRM).
Rapid immune reconstitution following hematopoietic stem cell transplantation is essential for protection against infections and has been associated with lower incidence of cGVHD, relapse, and TRM. The mechanisms associated with the immune properties associated with CBT have not been fully investigated. The aim of this Research Topic is to gather the latest research, reviews and insights, providing an overview of the properties of CBT that can be useful for a better understanding of clinical outcomes of transplant survivors, and to give an update of treatment strategies to improve clinical management of these complications.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Stem cell treatment is a curative treatment option for many hematological malignancies and cord blood transplantation (CBT) represents an alternative source of hematopoietic stem cells for patients who lack a suitable related or unrelated donor. CBT is associated with lower rates of chronic graft-versus-host disease (cGVHD), and relapse; however a low stem cell content in the graft results in slower immune reconstitution, higher risk of graft failure, severe infections, and transplant-related mortality (TRM).
Rapid immune reconstitution following hematopoietic stem cell transplantation is essential for protection against infections and has been associated with lower incidence of cGVHD, relapse, and TRM. The mechanisms associated with the immune properties associated with CBT have not been fully investigated. The aim of this Research Topic is to gather the latest research, reviews and insights, providing an overview of the properties of CBT that can be useful for a better understanding of clinical outcomes of transplant survivors, and to give an update of treatment strategies to improve clinical management of these complications.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
