Research Topic

New translational insights on Metabolic Syndrome: Obesity, Hypertension, Diabetes and beyond

About this Research Topic

Hypertension alone is a serious condition, but when a patient has high blood pressure along with diabetes and obesity, this patient may be diagnosed with metabolic syndrome. Such combination of risk factors assures a greater chance that this patient will have cardiovascular diseases. Therefore, metabolic ...

Hypertension alone is a serious condition, but when a patient has high blood pressure along with diabetes and obesity, this patient may be diagnosed with metabolic syndrome. Such combination of risk factors assures a greater chance that this patient will have cardiovascular diseases. Therefore, metabolic syndrome is a serious health condition that affects about 34 percent of adults in United States and places them at higher risk of cardiovascular disease, diabetes, stroke and other diseases related to arteriosclerosis.

Metabolic syndrome occurs when a patient presents at least three of the following factors: abdominal obesity, triglyceride level of 150 milligrams per deciliter of blood (mg/dL) or greater, HDL cholesterol of less than 40 mg/dL in men or less than 50 mg/dL in women, systolic blood pressure of 130 mm Hg or greater, or diastolic blood pressure of 85 mm Hg or greater and fasting glucose of 100 mg/dL or greater.

There are several underlying causes of metabolic syndrome including overweight and obesity, physical inactivity and genetic factors. However, the underlying mechanisms that leads to metabolic syndrome are still unknown. Therefore, the aim of this research topic is to shed some light on the mechanisms underlying the appearance and development of most of the risk factors presented in metabolic syndrome, mostly from translational research worldwide. Of note, the role of new components of the renin-angiotensin system such as ADAM17, oxidative stress, new nitric oxide donors, brain nuclear transcriptional factors and other signaling molecules in several aspects of metabolic syndrome will be explored. Finally, new perspectives of strategies for treating the metabolic syndrome will be proposed.


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