Extracellular vesicles (EVs) comprise several kinds of cell-derived vesicles that carry various signaling molecules including lipids, proteins, RNA, and DNA. EVs are produced by almost all cell types and there are different routes for their biogenesis. EVs can mimic cell-cell contact communications and spread to nearby cells within the tissue and also transmit signals longer distances, between organs. The molecular composition of EVs, in particular the enrichment of microRNA, specific set of receptors, growth factors, epigenetic regulatory molecules makes them valuable players of key cellular processes, such as proliferation, differentiation, migration and invasion. Accordingly, EVs are key mediators of angiogenesis, cell differentiation, inflammation, cancer development and tissue regeneration, both in normal and pathological conditions. The altered expression of proteins and RNAs within EVs in changing normal and pathological conditions can shed light on the molecular mechanisms of different processes and proposes new therapeutic targets and tools.
Immune cells pay pivotal role in tissue regeneration and cancer. Phagocytic myeloid cells are primary EV targets and thus are crucial mediators of their impact on these processes. EVs carry various factors that permit them to reprogram immune cells. These include antigens or antigen receptors with functional coreceptors, regulatory and stimulatory factors and genetic material. Of special interest is extracellular RNA that is carried exclusively by EVs and can regulate gene expression in target cells all over the body.
Better understanding of the cellular communications performed by EVs and their components could reveal early signs of diseases such as chronic inflammation, cancer, fibrosis, diabetes, cardiovascular, and neurological disorders. Therefore, in this research topic we encourage submission of original research papers and reviews dedicated to EV regulation of immune response in tissue damage or pathological chronic inflammation.
We encourage particularly contributions that include, but are not limited to, the following topics:
• EVs regulation of immune response
• Immunosuppression orchestrated by EVs in tissue regeneration and cancer
• EVs in cell renewal and tissue regeneration
• Different types of RNAs revealed in EVs
• EVs as mediators of the targeted horizontal gene transfer
• EVs as disease biomarkers
• Therapeutic application of EVs
Extracellular vesicles (EVs) comprise several kinds of cell-derived vesicles that carry various signaling molecules including lipids, proteins, RNA, and DNA. EVs are produced by almost all cell types and there are different routes for their biogenesis. EVs can mimic cell-cell contact communications and spread to nearby cells within the tissue and also transmit signals longer distances, between organs. The molecular composition of EVs, in particular the enrichment of microRNA, specific set of receptors, growth factors, epigenetic regulatory molecules makes them valuable players of key cellular processes, such as proliferation, differentiation, migration and invasion. Accordingly, EVs are key mediators of angiogenesis, cell differentiation, inflammation, cancer development and tissue regeneration, both in normal and pathological conditions. The altered expression of proteins and RNAs within EVs in changing normal and pathological conditions can shed light on the molecular mechanisms of different processes and proposes new therapeutic targets and tools.
Immune cells pay pivotal role in tissue regeneration and cancer. Phagocytic myeloid cells are primary EV targets and thus are crucial mediators of their impact on these processes. EVs carry various factors that permit them to reprogram immune cells. These include antigens or antigen receptors with functional coreceptors, regulatory and stimulatory factors and genetic material. Of special interest is extracellular RNA that is carried exclusively by EVs and can regulate gene expression in target cells all over the body.
Better understanding of the cellular communications performed by EVs and their components could reveal early signs of diseases such as chronic inflammation, cancer, fibrosis, diabetes, cardiovascular, and neurological disorders. Therefore, in this research topic we encourage submission of original research papers and reviews dedicated to EV regulation of immune response in tissue damage or pathological chronic inflammation.
We encourage particularly contributions that include, but are not limited to, the following topics:
• EVs regulation of immune response
• Immunosuppression orchestrated by EVs in tissue regeneration and cancer
• EVs in cell renewal and tissue regeneration
• Different types of RNAs revealed in EVs
• EVs as mediators of the targeted horizontal gene transfer
• EVs as disease biomarkers
• Therapeutic application of EVs
