To survive, all living cells, tissues, and organisms must cope with a litany of intrinsic and environmental insults. Such insults often result in perturbations to fundamental processes that affect their intended final output unless optimal function is restored. Eukaryotic cells are uniquely equipped to tackle such insults, due in part to the compartmentalized nature of their processing activities within membrane bound organelles and the cytoplasm. Indeed, research in the past few decades has highlighted the paradigmatic ability of cells to adapt and respond to perturbations and maintain the homeostasis of cellular processes. These adaptive responses are often initiated at specific sub-cellular locations and are governed by dedicated networks of signaling and transcriptional programs that either correct and restore the optimal function of a perturbed process, or if unmitigated, result in abortive cell death. The focus of this research topic is to discuss the complexity of the signaling circuits that function to regulate the homeostasis of protein synthesis, folding and secretion.
The aim of this article series is to generate a systems-level integrated view of eukaryotic stress response pathways that regulate protein homeostasis in the cytoplasm, endoplasmic reticulum, and the Golgi apparatus. Recent advances in systems-wide experimental approaches and the application of mathematical and engineering principles to model and map biological signaling circuits has enriched our understanding of the cellular responses to specific perturbations to the processes of protein synthesis, folding and secretion. These studies have uncovered multiple layers of regulation and highlighted an as yet unknown significance for molecular cross-talk between distinct stress response pathways. It would be therefore of interest to highlight how these stress-activated signaling circuits converge on the regulation of the quality and quantity of secreted proteins.
We welcome authors from the fields of biology and engineering to submit original research articles and reviews on the roles of cellular circuits that sense and respond to cell intrinsic and cell extrinsic perturbations to preserve the optimality of protein synthesis, folding and secretion. The following topics are of particular interest
• Signaling circuits on the endoplasmic reticulum (for example unfolded protein response, ER overload response, signaling at ER exit sites, ER-phagy).
• Signaling circuits on the Golgi apparatus
• Integrated stress response
• Ribotoxic stress response
To survive, all living cells, tissues, and organisms must cope with a litany of intrinsic and environmental insults. Such insults often result in perturbations to fundamental processes that affect their intended final output unless optimal function is restored. Eukaryotic cells are uniquely equipped to tackle such insults, due in part to the compartmentalized nature of their processing activities within membrane bound organelles and the cytoplasm. Indeed, research in the past few decades has highlighted the paradigmatic ability of cells to adapt and respond to perturbations and maintain the homeostasis of cellular processes. These adaptive responses are often initiated at specific sub-cellular locations and are governed by dedicated networks of signaling and transcriptional programs that either correct and restore the optimal function of a perturbed process, or if unmitigated, result in abortive cell death. The focus of this research topic is to discuss the complexity of the signaling circuits that function to regulate the homeostasis of protein synthesis, folding and secretion.
The aim of this article series is to generate a systems-level integrated view of eukaryotic stress response pathways that regulate protein homeostasis in the cytoplasm, endoplasmic reticulum, and the Golgi apparatus. Recent advances in systems-wide experimental approaches and the application of mathematical and engineering principles to model and map biological signaling circuits has enriched our understanding of the cellular responses to specific perturbations to the processes of protein synthesis, folding and secretion. These studies have uncovered multiple layers of regulation and highlighted an as yet unknown significance for molecular cross-talk between distinct stress response pathways. It would be therefore of interest to highlight how these stress-activated signaling circuits converge on the regulation of the quality and quantity of secreted proteins.
We welcome authors from the fields of biology and engineering to submit original research articles and reviews on the roles of cellular circuits that sense and respond to cell intrinsic and cell extrinsic perturbations to preserve the optimality of protein synthesis, folding and secretion. The following topics are of particular interest
• Signaling circuits on the endoplasmic reticulum (for example unfolded protein response, ER overload response, signaling at ER exit sites, ER-phagy).
• Signaling circuits on the Golgi apparatus
• Integrated stress response
• Ribotoxic stress response
