G protein-coupled receptors: neuromodulation and diseases

298.9K

views

98

authors

16

articles

G protein-coupled receptors: neuromodulation and diseases

298.9K

views

98

authors

16

articles

Editors

1

University of Toronto

Impact

About

G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane receptors that recognize a diverse array of extracellular stimuli and widely exist in the central nervous system. These receptors modulate the key neurotransmitter systems and participate in many different cellular processes that could be disrupted in human diseases. Thus, GPCRs become potential therapeutic targets for a range of neurological and psychiatric disorders.

This research topic focuses on roles of GPCRs in modulating synaptic transmission, plasticity and higher brain functions in neurological (neurodevelopmental and neurodegenerative) and psychiatric diseases. The scope of this research topic includes, but is not limited to: deficits in GPCRs and their downstream signaling pathways in disease model organisms; molecular mechanisms underlying disruption of GPCR signalings in neurological and psychiatric disorders; modulation of neurotransmitter systems and synaptic plasticity by GPCRs in disease conditions; neural and behavioral responses to potential therapeutic strategies targeting GPCRs in disease model systems and the translational relevance of those targets to patients with neurological or psychiatric disorders.

G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane receptors that recognize a diverse array of extracellular stimuli and widely exist in the central nervous system. These receptors modulate the key neurotransmitter systems and participate in many different cellular processes that could be disrupted in human diseases. Thus, GPCRs become potential therapeutic targets for a range of neurological and psychiatric disorders.

This research topic focuses on roles of GPCRs in modulating synaptic transmission, plasticity and higher brain functions in neurological (neurodevelopmental and neurodegenerative) and psychiatric diseases. The scope of this research topic includes, but is not limited to: deficits in GPCRs and their downstream signaling pathways in disease model organisms; molecular mechanisms underlying disruption of GPCR signalings in neurological and psychiatric disorders; modulation of neurotransmitter systems and synaptic plasticity by GPCRs in disease conditions; neural and behavioral responses to potential therapeutic strategies targeting GPCRs in disease model systems and the translational relevance of those targets to patients with neurological or psychiatric disorders.

Share

Editors

University of Toronto

Impact

298,873 Total views

255,415 Article views

37,689 Article downloads

5,769 Topic views

Published In

Journal Thumbnail

Frontiers in Pharmacology

Neuropharmacology

Journal Thumbnail

Frontiers in Cellular Neuroscience

Cellular Neuroscience Archive, Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

Journal Thumbnail

Frontiers in Neuroscience

Neuropharmacology

Journal Thumbnail

Frontiers in Physiology

Integrative Physiology

Journal Thumbnail

Frontiers in Psychiatry

Neuropharmacology

Journal Thumbnail

Frontiers in Neurology

Neuropharmacology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic