The incidence of gynecologic malignancies diagnosed during pregnancy has substantially increased in recent decades, due to an older pregnant population. Coupled with the fact that cervical cancer, ovarian cancer, and vulvar and vaginal cancer are the most common cancers diagnosed in pregnancy, the rare and uncommon cases, such as hydatidiform mole and leiomyosarcoma have also been reported. However, decisions regarding clinical diagnosis and oncological treatment pose a great number of unique challenges, because of the safety of surgical and chemotherapeutic treatments in pregnancy to be considered in terms of both oncologic and fetal outcomes, as well as the potential loss of the patient’s future reproductive capacity. A multidisciplinary approach should be convened, while individualization of treatment is also mandatory, based on tumor type, stage, and gestational age at the time of diagnosis.
At present, the challenge of management is the lack of early screening of the oncologic population and evidence-based data on the safety of therapeutic procedures on pregnant women and children in long-term follow-up. Therefore, collaborative efforts to expand knowledge, improve clinical approach as well new strategies for early detection can promote effective management of pregnant women with gynecologic cancers and their offspring.
This Research Topic aims at gathering the expanding knowledge on gynecologic malignancies during pregnancy that provides new and personalized strategies for diagnosing and predicting the prognosis of gynecologic malignant tumors. Our goal is to promote the development of early detection and appropriate treatment to optimize the oncological outcome and achieve excellent obstetric outcomes.
We welcome submissions of Original Research, Review, Perspective, and Opinion articles involving clinical and basic studies, covering but not limited to the following subtopics:
• Approaches to improve early screening for gynecologic malignant tumors in pregnant women.
• Comparison of maternal and fetal outcomes, risks, and benefits in individualization therapeutic options in oncologic women.
• Comparison of different treatments and outcomes when cancers are diagnosed at different gestational ages.
• Evaluation of the possibility of fertility-sparing oncologic surgery.
• Long-term studies on children treated with surgical or chemotherapeutic management in utero to analyze the downstream effects of the treatment.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The incidence of gynecologic malignancies diagnosed during pregnancy has substantially increased in recent decades, due to an older pregnant population. Coupled with the fact that cervical cancer, ovarian cancer, and vulvar and vaginal cancer are the most common cancers diagnosed in pregnancy, the rare and uncommon cases, such as hydatidiform mole and leiomyosarcoma have also been reported. However, decisions regarding clinical diagnosis and oncological treatment pose a great number of unique challenges, because of the safety of surgical and chemotherapeutic treatments in pregnancy to be considered in terms of both oncologic and fetal outcomes, as well as the potential loss of the patient’s future reproductive capacity. A multidisciplinary approach should be convened, while individualization of treatment is also mandatory, based on tumor type, stage, and gestational age at the time of diagnosis.
At present, the challenge of management is the lack of early screening of the oncologic population and evidence-based data on the safety of therapeutic procedures on pregnant women and children in long-term follow-up. Therefore, collaborative efforts to expand knowledge, improve clinical approach as well new strategies for early detection can promote effective management of pregnant women with gynecologic cancers and their offspring.
This Research Topic aims at gathering the expanding knowledge on gynecologic malignancies during pregnancy that provides new and personalized strategies for diagnosing and predicting the prognosis of gynecologic malignant tumors. Our goal is to promote the development of early detection and appropriate treatment to optimize the oncological outcome and achieve excellent obstetric outcomes.
We welcome submissions of Original Research, Review, Perspective, and Opinion articles involving clinical and basic studies, covering but not limited to the following subtopics:
• Approaches to improve early screening for gynecologic malignant tumors in pregnant women.
• Comparison of maternal and fetal outcomes, risks, and benefits in individualization therapeutic options in oncologic women.
• Comparison of different treatments and outcomes when cancers are diagnosed at different gestational ages.
• Evaluation of the possibility of fertility-sparing oncologic surgery.
• Long-term studies on children treated with surgical or chemotherapeutic management in utero to analyze the downstream effects of the treatment.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.