Tumor microenvironment (TME) and tumor cells are mutually reinforcing. TME is a highly complex and heterogeneous system that is mainly composed of tumor (stem) cells, surrounding immune and inflammatory cells, tumor-associated fibroblasts, adjacent stromal tissues, microvessels, as well as various cytokines and chemokines. The heterogeneity of TME is closely related to the response to anti-tumor therapy in patients. RNA modification is one of the most important sources of heterogeneity in both tumors and TME. Therefore, elucidating the regulation and implications of abnormal RNA modifications in TME will not only reach a better understanding of the systemic interaction between tumor cells and the microenvironment but also benefit anti-tumor therapies, including chemotherapy, radiotherapy, and immunotherapy. It is of great importance to identify abnormal RNA modifications, RNA modification-related signaling pathways, and regulatory mechanisms involved in the TME, to develop modulators of RNA modification systems beneficial for anti-tumor therapeutics, and to optimize methods used to discover, detect, and investigate RNA modifications in the TME.
Accumulating evidence suggests that RNA modifications play a vital role in reshaping the TME that supports malignant cells. This Frontiers Research Topic aims to reveal the intricate ternary networks of RNA modification system, TME, and tumor cells, to extend the understanding of the role and regulatory mechanisms of RNA modifications in TME, to explore the reasons for poor response to anti-tumor therapy in patients caused by TME heterogeneity, to develop methods those can accelerate the research of the networks of RNA modification system, TME, and tumor cells, and to benefit anti-tumor strategies against tumorigenesis, progression, immune escape, and drug resistance.
In this Research Topic, we would like to focus on the abnormity of the RNA modification systems in TME. We welcome submissions of Original Research Articles, Reviews, and Mini-reviews covering but not limited to the following topics:
• Identifying specific RNA modifications, RNA modification-related regulators, and signaling pathways modulating the TME in individual cancer.
• Elucidating the regulatory mechanisms of abnormal RNA modification system in TME.
• Revealing the TME heterogeneity caused by RNA modification system or epitranscriptome.
• Developing modulators of RNA modification system or TME to benefit anti-tumor therapeutics, including chemotherapy, radiotherapy, and immunotherapy.
• Methodology research for TME. Establishing or optimizing methods used to discover, detect, and/or investigate RNA modification in TME.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Tumor microenvironment (TME) and tumor cells are mutually reinforcing. TME is a highly complex and heterogeneous system that is mainly composed of tumor (stem) cells, surrounding immune and inflammatory cells, tumor-associated fibroblasts, adjacent stromal tissues, microvessels, as well as various cytokines and chemokines. The heterogeneity of TME is closely related to the response to anti-tumor therapy in patients. RNA modification is one of the most important sources of heterogeneity in both tumors and TME. Therefore, elucidating the regulation and implications of abnormal RNA modifications in TME will not only reach a better understanding of the systemic interaction between tumor cells and the microenvironment but also benefit anti-tumor therapies, including chemotherapy, radiotherapy, and immunotherapy. It is of great importance to identify abnormal RNA modifications, RNA modification-related signaling pathways, and regulatory mechanisms involved in the TME, to develop modulators of RNA modification systems beneficial for anti-tumor therapeutics, and to optimize methods used to discover, detect, and investigate RNA modifications in the TME.
Accumulating evidence suggests that RNA modifications play a vital role in reshaping the TME that supports malignant cells. This Frontiers Research Topic aims to reveal the intricate ternary networks of RNA modification system, TME, and tumor cells, to extend the understanding of the role and regulatory mechanisms of RNA modifications in TME, to explore the reasons for poor response to anti-tumor therapy in patients caused by TME heterogeneity, to develop methods those can accelerate the research of the networks of RNA modification system, TME, and tumor cells, and to benefit anti-tumor strategies against tumorigenesis, progression, immune escape, and drug resistance.
In this Research Topic, we would like to focus on the abnormity of the RNA modification systems in TME. We welcome submissions of Original Research Articles, Reviews, and Mini-reviews covering but not limited to the following topics:
• Identifying specific RNA modifications, RNA modification-related regulators, and signaling pathways modulating the TME in individual cancer.
• Elucidating the regulatory mechanisms of abnormal RNA modification system in TME.
• Revealing the TME heterogeneity caused by RNA modification system or epitranscriptome.
• Developing modulators of RNA modification system or TME to benefit anti-tumor therapeutics, including chemotherapy, radiotherapy, and immunotherapy.
• Methodology research for TME. Establishing or optimizing methods used to discover, detect, and/or investigate RNA modification in TME.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
