Research Topic

The roles of GnIH in reproductive function and behavior

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Since the discovery of gonadotropin-releasing hormone (GnRH) at the beginning of 1970s, it has been believed that GnRH is the only hypothalamic neuropeptide that regulates gonadotropin release in vertebrates. In 2000, however, a novel hypothalamic neuropeptide that actively inhibits gonadotropin release was ...

Since the discovery of gonadotropin-releasing hormone (GnRH) at the beginning of 1970s, it has been believed that GnRH is the only hypothalamic neuropeptide that regulates gonadotropin release in vertebrates. In 2000, however, a novel hypothalamic neuropeptide that actively inhibits gonadotropin release was discovered in quail and termed gonadotropin-inhibitory hormone (GnIH). GnIH is one of the RFamide peptides and it is also known as RFamide-related peptide (RFRP) in mammals. Following fourteen years of research has revealed that GnIH is highly conserved across vertebrates including humans, and GnIH is involved in a number of physiological and behavioral functions related to reproduction. The aim of this Research Topic is to celebrate the discovery of GnIH and the progress in GnIH research by gathering review papers and original articles from leading scientists in this new research field. This research topic invites authors who contributed to the discovery and identification of GnIH peptides and their functions, which greatly contributed to the progress of Reproductive Neuroendocrinology.


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