Breast cancer is the most common malignancy in women worldwide. Advances in breast cancer prevention and treatment have achieved 90% five-year overall survival rate. However, a large number of patients breast cancers recur over the time, even 20 years after the initial diagnosis. Although there are multiple treatment options for breast cancer including endocrine therapy, chemotherapy, molecular targeted therapy, radiotherapy, and immunotherapy, there are still more than 40,000 breast cancer-related deaths annually in the US. Therefore, investigating molecular mechanisms of tumor progression, resistance and metastasis are crucial to better understand and identify at-risk patients and develop novel targets and treatment strategies in order to improve breast cancer patient prognosis.
The goals of this Research Topic are to elucidate the molecular mechanisms underlying cancer progression in patients with breast cancer. We aim to focus on identifying novel intrinsic and extrinsic molecular pathways. Furthermore, we will also focus on novel treatment proposals and innovative approaches to develop novel treatments and better identify patients who are at high risk of failing current standard approaches.
This research topic will discuss novel signaling pathways and therapy in breast cancer. Any original research and review manuscripts approaching research questions on the following topics are welcome:
• Tumor intrinsic signaling pathway in breast cancer
• Tumor microenvironment, including tumor immunity in breast cancer
• Predictive and prognostic biomarkers in breast cancer
• Novel therapeutic approaches for breast cancer
• Developing new animal models to study breast cancer
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Breast cancer is the most common malignancy in women worldwide. Advances in breast cancer prevention and treatment have achieved 90% five-year overall survival rate. However, a large number of patients breast cancers recur over the time, even 20 years after the initial diagnosis. Although there are multiple treatment options for breast cancer including endocrine therapy, chemotherapy, molecular targeted therapy, radiotherapy, and immunotherapy, there are still more than 40,000 breast cancer-related deaths annually in the US. Therefore, investigating molecular mechanisms of tumor progression, resistance and metastasis are crucial to better understand and identify at-risk patients and develop novel targets and treatment strategies in order to improve breast cancer patient prognosis.
The goals of this Research Topic are to elucidate the molecular mechanisms underlying cancer progression in patients with breast cancer. We aim to focus on identifying novel intrinsic and extrinsic molecular pathways. Furthermore, we will also focus on novel treatment proposals and innovative approaches to develop novel treatments and better identify patients who are at high risk of failing current standard approaches.
This research topic will discuss novel signaling pathways and therapy in breast cancer. Any original research and review manuscripts approaching research questions on the following topics are welcome:
• Tumor intrinsic signaling pathway in breast cancer
• Tumor microenvironment, including tumor immunity in breast cancer
• Predictive and prognostic biomarkers in breast cancer
• Novel therapeutic approaches for breast cancer
• Developing new animal models to study breast cancer
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.