About this Research Topic
This Research Topic will focus on materials as non-viral vectors for cellular uptake and delivery of genes and nucleic acids in order to achieve potential benefits to human health and advance gene therapy prospects. The aim of this Research Topic is to report current and future advancements in the use of materials, chemicals and particles as non-viral alternatives for nucleic acid delivery.
We welcome Original Research papers, Reviews, Mini-reviews or papers providing descriptions of novel methods for significantly advancing gene therapy. Themes of interest are limited to:
• Chemical gene/nucleic acid delivery systems (e.g. lipids, polymers, polyplexes, lipopolyplexes, silica, calcium phosphate)
• Engineered materials (e.g. MOFs, novel complexes, biobased/biomimetic materials, nanoparticles)
• Non-viral gene delivery as a research tool for investigating cellular processes
• Mechanisms of uptake and delivery
• Investigation of structure-function relationships between cargo nucleic acid and vector (e.g. genes, oligonucleotides, ncRNAs)
• Comparison with viral based systems
• Utility in various cell types, including expression in difficult to transfect cells (e.g. neurons or CAR-T cells)
Keywords: gene therapy, nucleic acid delivery, non-viral vectors, vectors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.