Microbiome is widely distributed in humans, such as intestinal tracts, respiratory tracts, reproductive tracts, skin, etc. Various environmental factors affect the microbial compositions, such as temperature, humidity, PH, oxygen content, etc. Affected by these environmental factors, microbiome in different locations of the human body has its characteristics. In addition, the microbial composition changes along with the altered host health states. On the other hand, the dysbiotic microbiome affects the health of the hosts through their metabolites. Exploring the bidirectional communications between microbiome and host will allow us to explore the pathogenesis of diseases and provide new perspectives for disease prediction or treatment.
Childhood is a critical period for the development of the body, immunity, and microbiome, and is closely related to the health in adulthood. In the past decade, numerous studies on the microbiome have illustrated the intimate relations between the microbiome and pediatric health, such as constipation, precocious puberty, autism, eczema, etc. Also, there are reports on diseases treatment through microbiome regulation. For example, the treatment of refractory constipation in children through probiotic administration, the treatment of allergic enteritis in children through fecal bacteria transplantation, etc. Therefore, microbiome is closely related to childhood health, and becoming a breakthrough in disease treatment and drug development.
This Research Topic invites original research and review articles which contribute to the understanding of the bidirectional communications between microbiome and host in childhood. Welcome submissions in the following subtopics, but not limited to:
• Interactions between host genetics and microbiome in childhood
• Signalling pathways for the communications between microbiome and hosts
• Pathogenesis of microbial dysbiosis in causing paediatric diseases
• Characteristics of the microbiome in children with different diseases and their response to clinical treatment
• Bioinformatic tools related to the metagenomic and meta-transcriptomic data analysis
• Databases for the respiratory, oral, and intestinal microbiome in children
Microbiome is widely distributed in humans, such as intestinal tracts, respiratory tracts, reproductive tracts, skin, etc. Various environmental factors affect the microbial compositions, such as temperature, humidity, PH, oxygen content, etc. Affected by these environmental factors, microbiome in different locations of the human body has its characteristics. In addition, the microbial composition changes along with the altered host health states. On the other hand, the dysbiotic microbiome affects the health of the hosts through their metabolites. Exploring the bidirectional communications between microbiome and host will allow us to explore the pathogenesis of diseases and provide new perspectives for disease prediction or treatment.
Childhood is a critical period for the development of the body, immunity, and microbiome, and is closely related to the health in adulthood. In the past decade, numerous studies on the microbiome have illustrated the intimate relations between the microbiome and pediatric health, such as constipation, precocious puberty, autism, eczema, etc. Also, there are reports on diseases treatment through microbiome regulation. For example, the treatment of refractory constipation in children through probiotic administration, the treatment of allergic enteritis in children through fecal bacteria transplantation, etc. Therefore, microbiome is closely related to childhood health, and becoming a breakthrough in disease treatment and drug development.
This Research Topic invites original research and review articles which contribute to the understanding of the bidirectional communications between microbiome and host in childhood. Welcome submissions in the following subtopics, but not limited to:
• Interactions between host genetics and microbiome in childhood
• Signalling pathways for the communications between microbiome and hosts
• Pathogenesis of microbial dysbiosis in causing paediatric diseases
• Characteristics of the microbiome in children with different diseases and their response to clinical treatment
• Bioinformatic tools related to the metagenomic and meta-transcriptomic data analysis
• Databases for the respiratory, oral, and intestinal microbiome in children
