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The aggravation of population aging is one of the most important social problems at present, which has attracted universal attention. It is of significant importance to developing innovative therapeutic strategies for age-related diseases.

Regenerative medicine refers to the use of biological and ...

The aggravation of population aging is one of the most important social problems at present, which has attracted universal attention. It is of significant importance to developing innovative therapeutic strategies for age-related diseases.

Regenerative medicine refers to the use of biological and engineering theories to restore functions of the damaged tissues and organs, which is a critical method used for age-related diseases. Currently, bioinformatics and computational approaches have been widely considered for the development of regenerative medicine. And the current research topic aims to cover recent advances in studies such as functional genomics, proteomics, metabolomics, and bioinformatics that bring in new perspectives on age-related diseases. Stem cell-based therapy has been widely used for age-related diseases, however, the limited availability of cell sources, the excessive cost, and the anticipated difficulties of clinical translation extensively restricted its application in the clinic. Some promising alternatives, inciting patients' innate ability of tissue regeneration, have the potential to provide new therapeutic options for tissue engineering and regenerative medicine, and also are the important content in our research topic.

Authors are invited to submit a manuscript. Relevant topics of interest to this special section include (but are not limited to):
• Preparation and application of biomaterials in age-related diseases
• Application of advanced therapies for tissue regeneration
• Non-cell therapy for age-related diseases
• Advanced bioinformatics approaches for drugs and advanced materials discovery and therapeutics in age-related diseases
• Stem cells and exosome-based treatments for age-related diseases
• Advanced immunotherapy strategy in age-related diseases

Please be aware that those manuscripts describing purely bioinformatic analyses without significant experimental validation would be out of scope.

Keywords: age-related diseases, biomaterials, stem cells, exosomes, immunotherapy


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