Multidrug resistance is increasing globally and recently, several investigations have recorded the existence of XDR and MDR bacterial pathogens in humans, animals, and in the food chain. Multidrug resistant (MDR) pathogens (superbugs) are currently one of the major critical current threats to public health. The rapid emergence of new resistance mechanisms and diminishing adequacy of treating common diseases has aborted the microbial response to classic treatment, resulting in long-term illness, increased health care spending, and an enormous risk of death. Generally, most etiological agents, especially bacterial pathogens showed high levels of multidrug resistance (MDR) with enhanced morbidity and mortality; thus, they are defined as “superbugs". Commonly, MDR bacteria are associated with nosocomial infections in humans and severe illness in different animal species. Additionally, certain MDR bacteria have become quite prevalent causes of community-acquired infections.
The aim of this Research Topic is to collect work on the current approaches to reduce the emergence of multidrug resistant virulent bacterial pathogens. With the aim of bridging gaps in knowledge relating to reducing antimicrobial resistance, biofilm development, and pathogenicity traits of human and animal bacterial pathogens which are considered a public health threat. Bearing in mind the significance of MDR, this Research Topic asserts the main issues associated with MDR and the need to understand its significance and mechanisms to combat microbial infections, different mechanisms of antimicrobial resistances, and virulence determinant of emerging MDR-pathogens. As a result this Research topic aims to offer a new window of possible multidisciplinary strategies based on current filed research.
This Research Topic welcomes studies on (but not limited to):
• Epidemiological studies illustrating the emergence of multidrug resistant pathogens of human and animal origins.
• Molecular investigations to explain the mechanism of antimicrobial resistance in MDR bacteria.
• Advanced molecular approaches used in identification of emerging MDR pathogens.
• Molecular investigations to examine the mechanism of biofilm inhibition and virulence attenuating effect of natural and synthetic antimicrobial agents.
• Epidemiological studies illustrating different strategies used to combat the spread of antimicrobial resistance.
Multidrug resistance is increasing globally and recently, several investigations have recorded the existence of XDR and MDR bacterial pathogens in humans, animals, and in the food chain. Multidrug resistant (MDR) pathogens (superbugs) are currently one of the major critical current threats to public health. The rapid emergence of new resistance mechanisms and diminishing adequacy of treating common diseases has aborted the microbial response to classic treatment, resulting in long-term illness, increased health care spending, and an enormous risk of death. Generally, most etiological agents, especially bacterial pathogens showed high levels of multidrug resistance (MDR) with enhanced morbidity and mortality; thus, they are defined as “superbugs". Commonly, MDR bacteria are associated with nosocomial infections in humans and severe illness in different animal species. Additionally, certain MDR bacteria have become quite prevalent causes of community-acquired infections.
The aim of this Research Topic is to collect work on the current approaches to reduce the emergence of multidrug resistant virulent bacterial pathogens. With the aim of bridging gaps in knowledge relating to reducing antimicrobial resistance, biofilm development, and pathogenicity traits of human and animal bacterial pathogens which are considered a public health threat. Bearing in mind the significance of MDR, this Research Topic asserts the main issues associated with MDR and the need to understand its significance and mechanisms to combat microbial infections, different mechanisms of antimicrobial resistances, and virulence determinant of emerging MDR-pathogens. As a result this Research topic aims to offer a new window of possible multidisciplinary strategies based on current filed research.
This Research Topic welcomes studies on (but not limited to):
• Epidemiological studies illustrating the emergence of multidrug resistant pathogens of human and animal origins.
• Molecular investigations to explain the mechanism of antimicrobial resistance in MDR bacteria.
• Advanced molecular approaches used in identification of emerging MDR pathogens.
• Molecular investigations to examine the mechanism of biofilm inhibition and virulence attenuating effect of natural and synthetic antimicrobial agents.
• Epidemiological studies illustrating different strategies used to combat the spread of antimicrobial resistance.