Macrophages are long-known for their property of phagocytosis of pathogens. However, they are now shown to be critical players in a variety of physiological and pathological phenomena. Microenvironment appears to have a strong influence on the plasticity and polarization of macrophages to elicit either protective or detrimental effects on the tissue or systemic homeostasis. Both oxidative and anaerobic metabolic pathways are immediate effectors of microenvironmental changes that directly determine physiological or pathological phenotype of macrophages. Research studies in the recent years have shed light on the role of macrophages and the secretome, in the pathology of a variety of disorders such as cardiovascular, central nervous system and malignant disorders, all of which involve a high degree of metabolic dysregulation. Therefore, it is a high time for a collection of articles that enhance our understanding of the role of macrophages in metabolic disorders.
This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of the role of macrophages in metabolic disorders. Potential areas of interest may include, but are not limited to:
- Diabetes and Obesity;
- Cardiovascular disorders;
- Alzheimer's disease or Related Disorders;
- Tissue injury and Regeneration.
We welcome submissions of different article types to this collection, especially reviews, mini-reviews, and original research papers.
Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.
Macrophages are long-known for their property of phagocytosis of pathogens. However, they are now shown to be critical players in a variety of physiological and pathological phenomena. Microenvironment appears to have a strong influence on the plasticity and polarization of macrophages to elicit either protective or detrimental effects on the tissue or systemic homeostasis. Both oxidative and anaerobic metabolic pathways are immediate effectors of microenvironmental changes that directly determine physiological or pathological phenotype of macrophages. Research studies in the recent years have shed light on the role of macrophages and the secretome, in the pathology of a variety of disorders such as cardiovascular, central nervous system and malignant disorders, all of which involve a high degree of metabolic dysregulation. Therefore, it is a high time for a collection of articles that enhance our understanding of the role of macrophages in metabolic disorders.
This Research Topic welcomes basic, translational, clinical, and applied research that improves our understanding of the role of macrophages in metabolic disorders. Potential areas of interest may include, but are not limited to:
- Diabetes and Obesity;
- Cardiovascular disorders;
- Alzheimer's disease or Related Disorders;
- Tissue injury and Regeneration.
We welcome submissions of different article types to this collection, especially reviews, mini-reviews, and original research papers.
Even though abstract submission is not mandatory, we encourage all interested researchers to submit an abstract before submitting their manuscript. Abstracts do not have to coincide with the final abstract of the manuscripts.