Skip to main content

About this Research Topic

Manuscript Submission Deadline 14 April 2023
Manuscript Extension Submission Deadline 15 May 2023

Plastic cell state change in both premalignant and malignant stages of solid tumor progression is regulated and coordinated by cellular processes as diverse as epigenome modification, transcription, splicing, translation, protein modification, proteostasis, intracellular trafficking, stress responses, ...

Plastic cell state change in both premalignant and malignant stages of solid tumor progression is regulated and coordinated by cellular processes as diverse as epigenome modification, transcription, splicing, translation, protein modification, proteostasis, intracellular trafficking, stress responses, metabolic rewiring and cell division. The intratumoral heterogeneity resulting from this plasticity drives disease progression phenotypes such as invasion, evasion of immune targeting, dormancy and therapy resistance.

Recent advances in understanding cellular plasticity include identification of autocrine, paracrine, matrix and mechanotransduction signaling between tumor cells and their microenvironment, including diverse architectures and stromal cell compartments.

This topic aims to publish primary and review articles that expand upon these advances and those that uncover new tumor microenvironment-derived regulatory mechanisms controlling plasticity in solid tumor progression. Studies that develop or implement methods/platforms to combine spatial and single-cell methodologies toward this end are of particular interest.

The editors welcome submissions which cover the following sub topics in relation to the mechanisms of cellular plasticity and progression of solid tumor development.

• Tumor-stroma crosstalk
• Therapy & stress resistance
• Immune evasion
• Dormancy & metastasis
• Extracellular matrix & mechanotransduction

Keywords: Solid Tumors, Single-Cell Analyses, Intratumoral Heterogeneity, Cellular Plasticity, Stress Responses, Cancer Evolution, Mechanobiology, Therapy Resistance, Immune Evasion, Premalignant Progression, Metastasis, Dormancy


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic Editors

Loading..

Topic Coordinators

Loading..

Recent Articles

Loading..

Articles

Sort by:

Loading..

Authors

Loading..

views

total views views downloads topic views

}
 
Top countries
Top referring sites
Loading..

Share on

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.