Cancer stem cells (CSCs) are a rare subpopulation of cancer tumor cells showing stem cell-like features, such as self-renewal, differentiation, and migration ability. CSCs have been reported in many different tumor types, such as breast cancer, colorectal cancer, and melanoma, and given their stemness phenotype, they are considered to be one of the major players in cancer drug resistance and relapse.
The molecular mechanisms that regulate CSCs origins and maintenance within the tumors are still not fully understood and their dynamic phenotype and extreme heterogeneity make it difficult to draw a comprehensive picture of their role in cancer development.
This Research Topic aims to provide new insights on the signaling pathways involved in CSCs phenotype and functions with the goal to identify novel therapeutic strategies to counteract them.
We are welcoming Original Research Articles and Reviews focused on, but not limited to:
- Molecular mechanisms implicated in CSC-induced cancer therapy resistance, migration, and invasion
- Dysregulated signaling pathways involved in CSCs
- New regulatory networks of CSCs signaling pathways
- CSCs signaling pathways involved in CSCs fate: quiescence, symmetric division or asymmetric division
- CSCs signaling pathways involved in tumor microenvironment interactions
- Therapeutic approaches to eradicate CSCs
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Cancer stem cells (CSCs) are a rare subpopulation of cancer tumor cells showing stem cell-like features, such as self-renewal, differentiation, and migration ability. CSCs have been reported in many different tumor types, such as breast cancer, colorectal cancer, and melanoma, and given their stemness phenotype, they are considered to be one of the major players in cancer drug resistance and relapse.
The molecular mechanisms that regulate CSCs origins and maintenance within the tumors are still not fully understood and their dynamic phenotype and extreme heterogeneity make it difficult to draw a comprehensive picture of their role in cancer development.
This Research Topic aims to provide new insights on the signaling pathways involved in CSCs phenotype and functions with the goal to identify novel therapeutic strategies to counteract them.
We are welcoming Original Research Articles and Reviews focused on, but not limited to:
- Molecular mechanisms implicated in CSC-induced cancer therapy resistance, migration, and invasion
- Dysregulated signaling pathways involved in CSCs
- New regulatory networks of CSCs signaling pathways
- CSCs signaling pathways involved in CSCs fate: quiescence, symmetric division or asymmetric division
- CSCs signaling pathways involved in tumor microenvironment interactions
- Therapeutic approaches to eradicate CSCs
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
