Cardiovascular Diseases (CVD) have been traditionally associated with several potentially modifiable risk factors such as Type 2 Diabetes Mellitus, Hypertension, Hyperlipidemia, and smoking. Though, other risk factors, such as autoimmunity and the rise of autoantibodies are also significant in the development of CVD. A number of epidemiological studies have shown these autoimmune diseases that are risk factors to CVD to be responsible for the significant reduction in the lifespan of affected individuals.
For example, Rheumatoid Arthritis, the most common inflammatory arthropathy in humans, is correlated with an increased risk of cardiovascular events, such as the association of anti-cyclic citrullinated peptide (anti-CCP) with ischemic cardiac arrest. Additionally, Systemic Lupus Erythematosus (SLE) is also associated with a significantly increased risk of cardiovascular morbidity and mortality; a pioneer in the field of CVD and autoimmune disorders, Prof. Murray B Urowitz, developed the bimodal mortality pattern of SLE. This theory relates the significant reduction in life expectancies of SLE patients with associated cardiovascular events and their fatal complications.
Given the association of inflammation in autoimmunity, the unusual production of cytokines may also be a substantial risk factor in the development of CVD. In animal models, pro-inflammatory Th-1 cytokines, such as IFN-?, were previously perceived to be atherogenic, though is supported with limited data. Further research is essential to understand the correlation between autoimmunity and CVD.
This Research Topic aims to create a forum to highlight novel insights into autoimmunity and CVD. We aim to provide readers a broad overview on the current and emerging research in this field. We welcome the submission of original research articles, systematic reviews, meta-analyses, and case reports.
Sub topics include but are not limited to:
1) Autoimmunity induced deep vein thrombosis.
2) Autoimmunity and cardiomyopathy.
3) Diabetes and cardiovascular disease.
4) Cytokine storm and blood hyper-coagulation.
5) Autoantibodies in aortic disease.
Cardiovascular Diseases (CVD) have been traditionally associated with several potentially modifiable risk factors such as Type 2 Diabetes Mellitus, Hypertension, Hyperlipidemia, and smoking. Though, other risk factors, such as autoimmunity and the rise of autoantibodies are also significant in the development of CVD. A number of epidemiological studies have shown these autoimmune diseases that are risk factors to CVD to be responsible for the significant reduction in the lifespan of affected individuals.
For example, Rheumatoid Arthritis, the most common inflammatory arthropathy in humans, is correlated with an increased risk of cardiovascular events, such as the association of anti-cyclic citrullinated peptide (anti-CCP) with ischemic cardiac arrest. Additionally, Systemic Lupus Erythematosus (SLE) is also associated with a significantly increased risk of cardiovascular morbidity and mortality; a pioneer in the field of CVD and autoimmune disorders, Prof. Murray B Urowitz, developed the bimodal mortality pattern of SLE. This theory relates the significant reduction in life expectancies of SLE patients with associated cardiovascular events and their fatal complications.
Given the association of inflammation in autoimmunity, the unusual production of cytokines may also be a substantial risk factor in the development of CVD. In animal models, pro-inflammatory Th-1 cytokines, such as IFN-?, were previously perceived to be atherogenic, though is supported with limited data. Further research is essential to understand the correlation between autoimmunity and CVD.
This Research Topic aims to create a forum to highlight novel insights into autoimmunity and CVD. We aim to provide readers a broad overview on the current and emerging research in this field. We welcome the submission of original research articles, systematic reviews, meta-analyses, and case reports.
Sub topics include but are not limited to:
1) Autoimmunity induced deep vein thrombosis.
2) Autoimmunity and cardiomyopathy.
3) Diabetes and cardiovascular disease.
4) Cytokine storm and blood hyper-coagulation.
5) Autoantibodies in aortic disease.