The current thematic proposal aims to explore, assimilate and push forward the current knowledge about the role of aberrant metabolism in immune modulatory processes evident in various diseased microenvironments. Immune checkpoint blockers (ICBs) are the currently the preferred therapeutic option in diseases where pathogens or abnormal cells block immune cell action. Most of this suppression is mediated via immuno-modulatory metabolites, that form a metabolic signaling pathway. However, ICBs have not lived up to their reputation, in a number of ailments, which has led to the advent of combination therapies, which combine ICBs together with targeting of metabolic mediators of therapy resistance. We are confident that the proposed thematic will be of interest to a wide range of audience of the journal especially those who are currently interested in therapeutic approaches in the emerging field of immunometabolism.
In human physiology, metabolic homeostasis takes center stage as a complex network of multi-enzyme systems working together transforms nutrients into macromolecule building blocks, energy currency, and biomass, all of which is clubbed under an umbrella term "cellular metabolism". However, in various diseased conditions, this homeostasis is altered leading to rewiring of these pathways. Metabolomics enables us to track these metabolic changes under particular settings associated with pathogens, hosts, or environmental co-effectors. Metabolic reprogramming in cancer cells involves promoting their abnormal growth and proliferation. Metabolic rewiring is widespread in biological systems as a immediate response to environmental, genetic, and diseased influences.
Contributors to this research topic can explore their interests in the emerging field of immunometabolomics, which deals metabolic processes that both aid and/or disrupt the action of immune cells against invading pathogens, abnormally proliferating host cells and resulting inflammation. For this research topic, the editors aim to include original articles, clinical case studies and reviews addressing immunometabolism and metabolic reprogramming of immune cells in normal physiology as well as in diseased conditions, with a special focus on infection, inflammation and cancer. Furthermore, this research topic aims to elucidate the potential benefits and/or drawbacks of therapeutic interventions targeting metabolic remodeling of immune cells in human physiology and disease.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation are considered out of scope of this section
The current thematic proposal aims to explore, assimilate and push forward the current knowledge about the role of aberrant metabolism in immune modulatory processes evident in various diseased microenvironments. Immune checkpoint blockers (ICBs) are the currently the preferred therapeutic option in diseases where pathogens or abnormal cells block immune cell action. Most of this suppression is mediated via immuno-modulatory metabolites, that form a metabolic signaling pathway. However, ICBs have not lived up to their reputation, in a number of ailments, which has led to the advent of combination therapies, which combine ICBs together with targeting of metabolic mediators of therapy resistance. We are confident that the proposed thematic will be of interest to a wide range of audience of the journal especially those who are currently interested in therapeutic approaches in the emerging field of immunometabolism.
In human physiology, metabolic homeostasis takes center stage as a complex network of multi-enzyme systems working together transforms nutrients into macromolecule building blocks, energy currency, and biomass, all of which is clubbed under an umbrella term "cellular metabolism". However, in various diseased conditions, this homeostasis is altered leading to rewiring of these pathways. Metabolomics enables us to track these metabolic changes under particular settings associated with pathogens, hosts, or environmental co-effectors. Metabolic reprogramming in cancer cells involves promoting their abnormal growth and proliferation. Metabolic rewiring is widespread in biological systems as a immediate response to environmental, genetic, and diseased influences.
Contributors to this research topic can explore their interests in the emerging field of immunometabolomics, which deals metabolic processes that both aid and/or disrupt the action of immune cells against invading pathogens, abnormally proliferating host cells and resulting inflammation. For this research topic, the editors aim to include original articles, clinical case studies and reviews addressing immunometabolism and metabolic reprogramming of immune cells in normal physiology as well as in diseased conditions, with a special focus on infection, inflammation and cancer. Furthermore, this research topic aims to elucidate the potential benefits and/or drawbacks of therapeutic interventions targeting metabolic remodeling of immune cells in human physiology and disease.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation are considered out of scope of this section
