Research Topic

Dynamic Interactions at Biological Membranes

  • Submission closed.

About this Research Topic

Plasma membranes and in general biomembranes establish and maintain differences in composition between the cell or organelle interior and exterior. Biomembranes are the site for cell-cell recognition, they allow active and passive transport of material into and out of the cell, and they harbor proteins as ...

Plasma membranes and in general biomembranes establish and maintain differences in composition between the cell or organelle interior and exterior. Biomembranes are the site for cell-cell recognition, they allow active and passive transport of material into and out of the cell, and they harbor proteins as initiators of signal transduction pathways.

This functional variety of biomembranes is intimately coupled to their organelle-specific, asymmetric composition. For example, eukaryotic cells harbor more than 1,000 different lipids varying in their headgroups and aliphatic chains. The composite nature of cell membranes consisting of a lipid bilayer with embedded membrane proteins was first described by the Singer-Nicolson fluid-mosaic model in 1972.

Subsequently, the passive role attributed to lipids in the fluid-mosaic model was expanded to a coupled organization of lipids and proteins in membranes, and the importance of protein-lipid interactions for the proper functioning of transporters and ion channels was recognized. The membrane model was further refined by the inclusion of the glycocalix and the cytoskeleton. The formation of membrane domains, the so-called tightly packed lipid rafts, was suggested to be essential for the coordination of membrane function e.g. in membrane trafficking and signalling.

Despite decades of scientific work on membranes, the onset of which can be traced to the first lipid bilayer model by Gorter and Grendel, many open questions persist regarding the relation of membrane composition, structure, and dynamics to the ability of membranes to laterally segregate and form domains with specific hydrophobic thickness, ordering, and lateral pressure, hence to make the membrane functional.

This Research Topic therefore addresses in particular (i) the mutual interaction of lipids and proteins, (ii) the composition-dependent formation of membrane (micro)domains, and, (iii) the influence of lipids on biological processes.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top