Both the immunologic evasion and the tumor promoting inflammation (rich in free radicals), as well as the induction of angiogenesis, are considered as important events in the induction of cancer, thus being regarded as hallmarks of cancer. These three phenomena are fine-tuned and orchestrated by the immune response; and certain pathogens, like Helicobacter pylori, human Papillomavirus (HPV), and more recently, helminth parasites, have been recognized as likely agents for the induction of one or more of these hallmarks. In spite of a growing field of evidence, this field lacks a comparison of the mechanisms of cancer induction by the different parasites. Such analysis should reveal important molecular targets for future drug development.
It has been thoroughly described that virulence factors from H. pylori, and oncoproteins from HPV are related to these parasites’-related oncogenesis. Moreover, secreted mitogens have been associated to helminth-dependent oncogenesis. Nonetheless, the inflammatory factors that are induced by these infections and may govern, to some extent, malignancy induction are yet to be explored profoundly, and a panorama about common and differing variables between these infections has not been drawn yet. In the present research topic we aim to configure a general model of infection-dependent inflammatory induction of cancer, with a special focus on finding common inflammatory targets that may help for future drug development.
This Research Topic is open to receive original articles, systematic and narrative reviews as well as meta-analysis on the following topics:
• Inflammatory mechanisms of oncogenesis
• Immunity, angiogenesis and tumor vascularization
• Parasite-related oncogenesis: inflammatory mechanisms
• Tumor-associated leukocytes: tumor associated macrophages, myeloid derived suppressor cells, T-regulatory cells, among others.
• The association of cytokine and chemokine signaling pathways with carcinogenesis
• Similarities and differences between the immune response to tumor associated parasites
• Immunogenicity of virulence factors, oncoproteins and parasite-produced mitogens
• Angiogenetic immunity and parasites: tumor establishment and metastasis
• Immune hypo-responsiveness and metastasis
• Tumor-related immune evasion: is it challenged or potentiated by bystander immune responses?
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Both the immunologic evasion and the tumor promoting inflammation (rich in free radicals), as well as the induction of angiogenesis, are considered as important events in the induction of cancer, thus being regarded as hallmarks of cancer. These three phenomena are fine-tuned and orchestrated by the immune response; and certain pathogens, like Helicobacter pylori, human Papillomavirus (HPV), and more recently, helminth parasites, have been recognized as likely agents for the induction of one or more of these hallmarks. In spite of a growing field of evidence, this field lacks a comparison of the mechanisms of cancer induction by the different parasites. Such analysis should reveal important molecular targets for future drug development.
It has been thoroughly described that virulence factors from H. pylori, and oncoproteins from HPV are related to these parasites’-related oncogenesis. Moreover, secreted mitogens have been associated to helminth-dependent oncogenesis. Nonetheless, the inflammatory factors that are induced by these infections and may govern, to some extent, malignancy induction are yet to be explored profoundly, and a panorama about common and differing variables between these infections has not been drawn yet. In the present research topic we aim to configure a general model of infection-dependent inflammatory induction of cancer, with a special focus on finding common inflammatory targets that may help for future drug development.
This Research Topic is open to receive original articles, systematic and narrative reviews as well as meta-analysis on the following topics:
• Inflammatory mechanisms of oncogenesis
• Immunity, angiogenesis and tumor vascularization
• Parasite-related oncogenesis: inflammatory mechanisms
• Tumor-associated leukocytes: tumor associated macrophages, myeloid derived suppressor cells, T-regulatory cells, among others.
• The association of cytokine and chemokine signaling pathways with carcinogenesis
• Similarities and differences between the immune response to tumor associated parasites
• Immunogenicity of virulence factors, oncoproteins and parasite-produced mitogens
• Angiogenetic immunity and parasites: tumor establishment and metastasis
• Immune hypo-responsiveness and metastasis
• Tumor-related immune evasion: is it challenged or potentiated by bystander immune responses?
Important Note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
