Coronaviruses are zoonoses viruses that belong to the Coronaviridae family of the Nidovirales order. Coronaviruses contain 4 genera: α, β, γ and δ. Among these, Alpha and Beta coronaviruses pose a major health threat to humans and other mammals. The severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic led to 8,000 people infected with a fatality of ~10% in 2002 and 2003. Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1,700 people, with a higher death rate of up to 35% since 2012. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic ravaged the globe from the end of 2019 till now, causing catastrophic health consequences. More than 521 million cases and more than 6 million deaths have been confirmed globally. And the variants of SARS-CoV-2 were conformed to escape the vaccine-induced neutralizing antibodies and immune system, causing break-through infection, and posing long-term threats.
SARS-CoV-2 is constantly evolving into new variants, creating global epidemic waves. Broad-spectrum antiviral targets or treatments are also urgently needed in the event of novel coronavirus cross-species transmission in the future. It is necessary to address new vaccine designs, pan drugs and antibodies, and universal mechanisms during viral infection.
Studies on broad-spectrum anti-coronavirus research will be the emphasis of this Research Topic. Original research and Review articles on current breakthroughs in our understanding of the broad-spectrum anti-coronavirus field are encouraged to be submitted. Topics may include, but are not limited to:
1. Universal mechanisms and pan anti-viral targets discovery during coronavirus entry, replication, assembly, and secretion
2. The recent advance of novel viral elements as anti-viral targets
3. Host factors during virus-host interaction as potential pan anti-coronavirus targets
4. Vaccine design and antibody screening against multiple coronaviruses
5. Broadly anti-viral drug design and screening.
Coronaviruses are zoonoses viruses that belong to the Coronaviridae family of the Nidovirales order. Coronaviruses contain 4 genera: α, β, γ and δ. Among these, Alpha and Beta coronaviruses pose a major health threat to humans and other mammals. The severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic led to 8,000 people infected with a fatality of ~10% in 2002 and 2003. Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1,700 people, with a higher death rate of up to 35% since 2012. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic ravaged the globe from the end of 2019 till now, causing catastrophic health consequences. More than 521 million cases and more than 6 million deaths have been confirmed globally. And the variants of SARS-CoV-2 were conformed to escape the vaccine-induced neutralizing antibodies and immune system, causing break-through infection, and posing long-term threats.
SARS-CoV-2 is constantly evolving into new variants, creating global epidemic waves. Broad-spectrum antiviral targets or treatments are also urgently needed in the event of novel coronavirus cross-species transmission in the future. It is necessary to address new vaccine designs, pan drugs and antibodies, and universal mechanisms during viral infection.
Studies on broad-spectrum anti-coronavirus research will be the emphasis of this Research Topic. Original research and Review articles on current breakthroughs in our understanding of the broad-spectrum anti-coronavirus field are encouraged to be submitted. Topics may include, but are not limited to:
1. Universal mechanisms and pan anti-viral targets discovery during coronavirus entry, replication, assembly, and secretion
2. The recent advance of novel viral elements as anti-viral targets
3. Host factors during virus-host interaction as potential pan anti-coronavirus targets
4. Vaccine design and antibody screening against multiple coronaviruses
5. Broadly anti-viral drug design and screening.