Cell differentiation and development occur naturally throughout an individual’s life, from embryo development to aging. The developmental programs are precisely organized and strictly regulated. Many diseases would result from uncontrolled cell growth or abnormal cell fate decisions. Our understanding of cell differentiation and regeneration mechanisms, both physiologically and pathologically, is currently insufficient and urgently needed.
With the advancement of single cell sequencing technologies, it is now possible to study the cell populations and their relationships in tissues and organs systematically. Discovering the key molecular signatures, transitional dynamics and cell-cell communication would be critical for deciphering the molecular mechanisms underlying normal tissue development and diseases, which eventually will facilitate novel therapeutic intervention development to prevent deleterious cell differentiation causing these diseases.
The aim of this Research Topic is to create a collection of articles that use single cell techniques to investigate cell developmental processes in both normal and disease conditions. Potential areas of focus include, but are not limited to:
1. Single cell studies of normal developmental and regenerative organs, such as embryo development;
2. Single cell studies of diseases focusing on the cellular differentiation and development;
3. Developmental related cancer research through single-cell methodologies, such as cancer stem cell, or cancer cell evolution studies;
4. Single cell studies in animal models for the purposes of understanding developmental related human diseases;
5. Biomarkers and therapeutic target discovery of understanding developmental related human diseases by single cell technologies;
6. Molecular mechanisms of cell development by single cell technologies；
7. New tools to analyze developmental processes on the single-cell level, including new experimental or computational methods, databases and models.
Topic Editor Dr. Jue Fan is employed by Singleron Biotechnologies, China. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Cell differentiation and development occur naturally throughout an individual’s life, from embryo development to aging. The developmental programs are precisely organized and strictly regulated. Many diseases would result from uncontrolled cell growth or abnormal cell fate decisions. Our understanding of cell differentiation and regeneration mechanisms, both physiologically and pathologically, is currently insufficient and urgently needed.
With the advancement of single cell sequencing technologies, it is now possible to study the cell populations and their relationships in tissues and organs systematically. Discovering the key molecular signatures, transitional dynamics and cell-cell communication would be critical for deciphering the molecular mechanisms underlying normal tissue development and diseases, which eventually will facilitate novel therapeutic intervention development to prevent deleterious cell differentiation causing these diseases.
The aim of this Research Topic is to create a collection of articles that use single cell techniques to investigate cell developmental processes in both normal and disease conditions. Potential areas of focus include, but are not limited to:
1. Single cell studies of normal developmental and regenerative organs, such as embryo development;
2. Single cell studies of diseases focusing on the cellular differentiation and development;
3. Developmental related cancer research through single-cell methodologies, such as cancer stem cell, or cancer cell evolution studies;
4. Single cell studies in animal models for the purposes of understanding developmental related human diseases;
5. Biomarkers and therapeutic target discovery of understanding developmental related human diseases by single cell technologies;
6. Molecular mechanisms of cell development by single cell technologies；
7. New tools to analyze developmental processes on the single-cell level, including new experimental or computational methods, databases and models.
Topic Editor Dr. Jue Fan is employed by Singleron Biotechnologies, China. All other Topic Editors declare no competing interests with regards to the Research Topic subject.