About this Research Topic
This research topic aims to highlight recent advances in bioengineered next-generation gene and cell therapy for modeling and treating cardiovascular diseases. As a multidisciplinary field, crosstalk between science, engineering, and clinic contributed to new products ranging from physiologically relevant disease models to specifically targeted delivery vehicles. For example, in vitro cardiovascular organoids in combination with microphysiological systems provide an excellent platform for preclinical testing. Novel organ-selective targeting lipid nanoparticles (LNPs) facilitate the delivery of gene products such as siRNA and modified mRNA. In addition, synthetic biology could inject the logic circuit into the stem cells and further program stem cells into fail-safe therapeutic cells much more efficiently compared to traditional differentiation.
We welcome contributions in the form of original research articles, review articles, mini-reviews, and perspectives on novel technologies for advancing gene- and cell-based therapy from the laboratory to the bedside. These include, but are not limited to:
1. Cell therapy
2. Stem cell and organoids
3. Genome and Epigenome editing
4. Gene therapy (viral and non-viral)
5. Gene-, and cellular delivery systems
Please note that clinical studies and manuscripts describing purely bioinformatic analyses of existing databases without significant experimental validation will not be accepted into this collection, as they are outside the scope of the Preclinical Cell and Gene Therapy section, of which this Research Topic is a part.
Keywords: gene therapy, cell therapy, delivery, gene editing, cancer, cardiovascular diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.