Mass spectrometry (MS) is an indispensable tool for analyzing various compounds and has been widely utilized in chemistry, medicine, and pharmaceutical research. Mass spectrometry-based techniques have played a vital role in the qualitative and quantitative analysis of proteins, nucleic acids, and metabolites in various biological samples in the past few decades. As such, they have become the main driving force of various -omics techniques, including proteomics, metabolomics, lipidomics, etc. Nowadays, MS-based techniques are widely utilized in biomedical analysis to elucidate the underlying biological mechanisms of diseases, screen drugs, and discover novel biomarkers and molecular targets.
Combining MS with advanced separation tools such as gas chromatography (GC) or liquid chromatography (LC) significant enhances the ability to analyze complex biological samples such as serum, urine, saliva, and tissue. Besides electrospray ionization mass spectrometry (ESI-MS), matrix-assisted laser desorption mass spectrometry (MALDI-MS) is commonly used to analyze molecules with large molecular weight and also plays a vital role in biomedical analysis. In this Research Topic, we would like to attract high-quality manuscripts focusing on novel methodological advances of GC-MS, LC-MS, and MALDI-MS techniques in biomedical analysis, especially for the diagnosis, monitoring, and treatment of diseases as well as guiding drug development.
We welcome Original Research, Review, Mini Review, and Perspective articles on developing novel strategies for the methodology of mass-spectrometry-based techniques around the biomedical analysis. Specific themes may include, but are not limited to:
• MS-based proteomics, metabolomics, lipidomics, and other omics analysis.
• MS-based biomarker discovery for diagnosis and prognosis of diseases.
• MS-based drug target discovery and drug development.
Mass spectrometry (MS) is an indispensable tool for analyzing various compounds and has been widely utilized in chemistry, medicine, and pharmaceutical research. Mass spectrometry-based techniques have played a vital role in the qualitative and quantitative analysis of proteins, nucleic acids, and metabolites in various biological samples in the past few decades. As such, they have become the main driving force of various -omics techniques, including proteomics, metabolomics, lipidomics, etc. Nowadays, MS-based techniques are widely utilized in biomedical analysis to elucidate the underlying biological mechanisms of diseases, screen drugs, and discover novel biomarkers and molecular targets.
Combining MS with advanced separation tools such as gas chromatography (GC) or liquid chromatography (LC) significant enhances the ability to analyze complex biological samples such as serum, urine, saliva, and tissue. Besides electrospray ionization mass spectrometry (ESI-MS), matrix-assisted laser desorption mass spectrometry (MALDI-MS) is commonly used to analyze molecules with large molecular weight and also plays a vital role in biomedical analysis. In this Research Topic, we would like to attract high-quality manuscripts focusing on novel methodological advances of GC-MS, LC-MS, and MALDI-MS techniques in biomedical analysis, especially for the diagnosis, monitoring, and treatment of diseases as well as guiding drug development.
We welcome Original Research, Review, Mini Review, and Perspective articles on developing novel strategies for the methodology of mass-spectrometry-based techniques around the biomedical analysis. Specific themes may include, but are not limited to:
• MS-based proteomics, metabolomics, lipidomics, and other omics analysis.
• MS-based biomarker discovery for diagnosis and prognosis of diseases.
• MS-based drug target discovery and drug development.
