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Cancer Diagnostic and Therapeutic Target Identification and Verification based on the Regulatory Functions of MicroRNAs

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MicroRNAs (miRNAs), which are known as short (21-25 nucleotides), endogenous and non-coding RNA fragments, regulate target gene expression by binding to the complementary sequence motifs in 3’-untranslated region of the gene transcripts. With such regulatory function, miRNAs can be regarded as oncogenes or ...

MicroRNAs (miRNAs), which are known as short (21-25 nucleotides), endogenous and non-coding RNA fragments, regulate target gene expression by binding to the complementary sequence motifs in 3’-untranslated region of the gene transcripts. With such regulatory function, miRNAs can be regarded as oncogenes or tumor suppressor genes in human cancer. Moreover, miRNAs alter the acquired drug resistance and tumor progression and improve the treatment response to targeted therapy. Survey and original research studies, particularly in bioinformatics, single cell analysis, animal experiment and clinical trials, are very valuable for advancing the identification and verification of cancer diagnostic and therapeutic targets.


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