Our immune system acts as a guard against harmful stimuli and eliminates them before they cause damage. Although inflammatory signals are beneficial for the human body, when they become chronic they have the opposite effect. With the outbreak of the COVID-19 pandemic, the world’s attention is once again focused on pediatric inflammatory diseases due to the emergence of Multisystem Inflammatory Syndrome in children (MIS-C). The unknown etiology of MIS-C and many other pediatric inflammatory diseases limits the development of therapy options. Moreover, the lack of efficacy of current treatment options for several pediatric inflammatory diseases may result in permanent damage for individuals suffering from long-term health problems and can cause a dramatic decrease in their quality of life. In addition, the fact that infants have an underdeveloped immune system underlines that they have a weaker natural defense mechanism to combat diseases which in turn makes them even more vulnerable and may even cause their death. Overall, understanding the molecular basis of disease progression and analysis of novel treatment strategies for pediatric inflammatory diseases are valuable.
The purpose of this Research Topic is to gather data regarding the disease mechanisms, plausible therapy options, biomarkers, and unusual clinical observations on pediatric inflammatory diseases. We aim to collect both laboratory and clinical findings that may act as a bridge between bench and bedside.
This Research Topic aims to combine recent clinical and molecular discoveries regarding pediatric inflammatory diseases. Our objective is to cover the unknowns of immune regulation of childhood diseases and help scientists and clinicians to further investigate molecular mechanisms and possible therapy options. We are pleased to receive original research papers, case reports, commentaries, and review articles covering novel findings.
Submissions may address, but are not limited to:
1) Novel therapy options
2) Current treatment strategies
3) The molecular basis of the pediatric inflammatory diseases
4) Disease etiology in pediatric rheumatic diseases
5) Immune regulation
6) Biomarker discovery
7) Observational descriptive studies of pediatric rheumatic diseases
8) Diseases/conditions associated with a cytokine storm
9) Macrophage activation syndrome
10) MIS-C
11) Kawasaki Disease
12) Pediatric Inflammatory Bowel Disease
Our immune system acts as a guard against harmful stimuli and eliminates them before they cause damage. Although inflammatory signals are beneficial for the human body, when they become chronic they have the opposite effect. With the outbreak of the COVID-19 pandemic, the world’s attention is once again focused on pediatric inflammatory diseases due to the emergence of Multisystem Inflammatory Syndrome in children (MIS-C). The unknown etiology of MIS-C and many other pediatric inflammatory diseases limits the development of therapy options. Moreover, the lack of efficacy of current treatment options for several pediatric inflammatory diseases may result in permanent damage for individuals suffering from long-term health problems and can cause a dramatic decrease in their quality of life. In addition, the fact that infants have an underdeveloped immune system underlines that they have a weaker natural defense mechanism to combat diseases which in turn makes them even more vulnerable and may even cause their death. Overall, understanding the molecular basis of disease progression and analysis of novel treatment strategies for pediatric inflammatory diseases are valuable.
The purpose of this Research Topic is to gather data regarding the disease mechanisms, plausible therapy options, biomarkers, and unusual clinical observations on pediatric inflammatory diseases. We aim to collect both laboratory and clinical findings that may act as a bridge between bench and bedside.
This Research Topic aims to combine recent clinical and molecular discoveries regarding pediatric inflammatory diseases. Our objective is to cover the unknowns of immune regulation of childhood diseases and help scientists and clinicians to further investigate molecular mechanisms and possible therapy options. We are pleased to receive original research papers, case reports, commentaries, and review articles covering novel findings.
Submissions may address, but are not limited to:
1) Novel therapy options
2) Current treatment strategies
3) The molecular basis of the pediatric inflammatory diseases
4) Disease etiology in pediatric rheumatic diseases
5) Immune regulation
6) Biomarker discovery
7) Observational descriptive studies of pediatric rheumatic diseases
8) Diseases/conditions associated with a cytokine storm
9) Macrophage activation syndrome
10) MIS-C
11) Kawasaki Disease
12) Pediatric Inflammatory Bowel Disease
