Intraoperative radiotherapy (IORT) has been used in either adjuvant or palliative settings for various types of neoplasms, such as head and neck, breast, stomach, pancreas, colorectal, genitourinary, gynecological cancers, and retroperitoneal soft-tissue sarcomas. In most cases, local control can be successfully obtained by IORT with or without external beam radiotherapy. From the oncological point of view, much evidence has been accumulated in breast cancer, however, in gastrointestinal cancers, the number of randomized controlled studies and meta-analyses is still limited, and large amounts of evidence have not been obtained.
Local control rate after R0/R1 resection for gastrointestinal (GI) malignancy is enhanced by IORT, however, some researchers claimed that high dose radiation may destroy the microenvironment around the tumor, and damage the local immunity, leading to increase distant metastasis. Are there any clinical and/or basic findings to support this phenomenon?
In this Research Topic, we aim to accumulate recent clinical and basic findings on IORT in the treatment of GI malignancy. The advantages and disadvantages of IORT in the treatment of GI malignancy should be discussed comprehensively.
Potential topics include but are not limited to the following.
1) Randomized controlled trials
2) Meta-analyses
3) Case reports of unexpected oncological or functional outcomes after IORT
4) Basic studies on GI cancer cell invasion and metastasis after high dose radiation exposure
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Intraoperative radiotherapy (IORT) has been used in either adjuvant or palliative settings for various types of neoplasms, such as head and neck, breast, stomach, pancreas, colorectal, genitourinary, gynecological cancers, and retroperitoneal soft-tissue sarcomas. In most cases, local control can be successfully obtained by IORT with or without external beam radiotherapy. From the oncological point of view, much evidence has been accumulated in breast cancer, however, in gastrointestinal cancers, the number of randomized controlled studies and meta-analyses is still limited, and large amounts of evidence have not been obtained.
Local control rate after R0/R1 resection for gastrointestinal (GI) malignancy is enhanced by IORT, however, some researchers claimed that high dose radiation may destroy the microenvironment around the tumor, and damage the local immunity, leading to increase distant metastasis. Are there any clinical and/or basic findings to support this phenomenon?
In this Research Topic, we aim to accumulate recent clinical and basic findings on IORT in the treatment of GI malignancy. The advantages and disadvantages of IORT in the treatment of GI malignancy should be discussed comprehensively.
Potential topics include but are not limited to the following.
1) Randomized controlled trials
2) Meta-analyses
3) Case reports of unexpected oncological or functional outcomes after IORT
4) Basic studies on GI cancer cell invasion and metastasis after high dose radiation exposure
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
