Hypertension is a leading risk factor for morbidity and mortality of cardiovascular disease. It is a low-grade chronic systemic inflammatory disease that results in target organ damage, including atherosclerosis, aneurysm, heart failure, atrial fibrillation, nephropathy, stroke, etc. Recently, immunity and inflammation have attracted growing attention due to their roles in the therapeutical potential in hypertension and cardiovascular and cerebrovascular diseases. Especially, alterations in both humoral and cellular immune functions have been identified in patients with essential hypertension.
Hypertensive stimuli (high salt, angiotensin II, aldosterone) induces immune cells (monocytes/macrophages, neutrophils, dendritic cells, NK cells, T cells, and B cells) activation and infiltration into kidney and vasculature, which produce pro-inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-17 and IL-6) and cause dysfunction of target organs and blood pressure elevation. Meanwhile, cells in heart, vasculature, kidney and brain also secrete chemokines (CCL2, CXCL1, CX3CL1) that recruit immune cells accelerate inflammatory response-mediated hypertension and target organ damage. Regarding humoral immunity, immunoglobulin levels IgG, IgA and IgM and complement factor C3 were found to be significantly increased in hypertension-associated cardiovascular diseases. However, despite their extensive number, more studies need to be carried out to investigate the therapeutical potential of immunity and inflammation on hypertension and cardiovascular and cerebrovascular diseases, which may lead to novel pharmacological treatment options in the clinic.
In this research topic, we would like to create a forum for current advances in immunity and inflammation mechanisms linking hypertension and hypertension-induced aneurysm, heart failure, atrial fibrillation, nephropathy, stroke and cardiovascular and cerebrovascular diseases.
Topics include but are not limited to the following ones:
- The function of immune cell subgroups
- The role of pro-inflammatory cytokines, chemokines and their receptors
- Crosstalk between immune cells and other cells in heart, vasculature, kidney and brain
- Dysregulation of immunoglobulin and complement
- Immunity and inflammation therapies
Hypertension is a leading risk factor for morbidity and mortality of cardiovascular disease. It is a low-grade chronic systemic inflammatory disease that results in target organ damage, including atherosclerosis, aneurysm, heart failure, atrial fibrillation, nephropathy, stroke, etc. Recently, immunity and inflammation have attracted growing attention due to their roles in the therapeutical potential in hypertension and cardiovascular and cerebrovascular diseases. Especially, alterations in both humoral and cellular immune functions have been identified in patients with essential hypertension.
Hypertensive stimuli (high salt, angiotensin II, aldosterone) induces immune cells (monocytes/macrophages, neutrophils, dendritic cells, NK cells, T cells, and B cells) activation and infiltration into kidney and vasculature, which produce pro-inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-17 and IL-6) and cause dysfunction of target organs and blood pressure elevation. Meanwhile, cells in heart, vasculature, kidney and brain also secrete chemokines (CCL2, CXCL1, CX3CL1) that recruit immune cells accelerate inflammatory response-mediated hypertension and target organ damage. Regarding humoral immunity, immunoglobulin levels IgG, IgA and IgM and complement factor C3 were found to be significantly increased in hypertension-associated cardiovascular diseases. However, despite their extensive number, more studies need to be carried out to investigate the therapeutical potential of immunity and inflammation on hypertension and cardiovascular and cerebrovascular diseases, which may lead to novel pharmacological treatment options in the clinic.
In this research topic, we would like to create a forum for current advances in immunity and inflammation mechanisms linking hypertension and hypertension-induced aneurysm, heart failure, atrial fibrillation, nephropathy, stroke and cardiovascular and cerebrovascular diseases.
Topics include but are not limited to the following ones:
- The function of immune cell subgroups
- The role of pro-inflammatory cytokines, chemokines and their receptors
- Crosstalk between immune cells and other cells in heart, vasculature, kidney and brain
- Dysregulation of immunoglobulin and complement
- Immunity and inflammation therapies