Research Topic

Molecular or cellular mechanisms of cognition and selective vulnerability in aging

  • Submission closed.

About this Research Topic

In older individuals with no significant cell loss, a vulnerability of specific cell types to senescence contributes to a decline in cognitive function. As our understanding of molecular and cellular processes for both aging and cognition increase we are likely to find that selective vulnerability can define ...

In older individuals with no significant cell loss, a vulnerability of specific cell types to senescence contributes to a decline in cognitive function. As our understanding of molecular and cellular processes for both aging and cognition increase we are likely to find that selective vulnerability can define impairments in particular cognitive domains and will thus define future therapeutic strategies. The effects of age on processes such as oxidative stress, energy metabolism, or DNA damage may differentially influence diverse cell types from excitatory and inhibitory neurons, oligodendrocytes, to cells of the blood brain barrier. Vulnerability of neurons may depend on their size, transmitter system, or location in neural circuits. In other cases, cells may be differentially sensitive due to the function of signaling pathways that underlie homeostasis or mediate cell specific processes involved in cognition (e.g. synaptic plasticity). Systemic influences of inflammation and hormonal status can alter the local milieu to influence different cell populations. Finally, genetic factors related to aging or cognition may define exceptional and pathological aging of specific neural circuits. The current series of articles outline mechanisms for cell selective vulnerability to aging and related these changes to cognitive decline.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top