The immune system plays important role in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer. IBD comprised of Crohn’s disease and ulcerative colitis is a manifestation of a dysregulated immune response against the intestinal mucosa. Moreover, Colitis-associated colorectal cancer (CAC) is considered the most serious complication of IBD.
Immune cells are the component of the intestinal microenvironment, they exert specific functions in intestinal tissue during IBD and CAC. They can secrete inflammatory cytokines, exosomes, and other cell factors. Also, immune cells could modulate other cell functions such as fibroblast in cell contact-dependent manners. The immunomodulatory role of immune cells to intestinal epithelial cells is essential to maintain intestinal tissue local immune homeostasis in infectious diseases and tumors. However, the molecular mechanisms underlying the complex functions between immune cells and intestinal epithelial cells in CAC immune surveillance and tumor evasion have not been identified.
This research topic aims to provide a comprehensive overview of immune cell roles in modulating intestinal epithelial cell functions in colon tissue immunopathology, such as inflammation, fibrosis, tumor, and other immune disorders, with particular focus on intestinal microorganism, cellular and molecular mechanisms driving tissue immuno-pathogenesis.
We welcome the submission of Original Research and Review articles that examine the role of the immune microenvironment in the development of IBD and CAC by modulating inflammatory factors and intestinal microorganisms. Subtopics include but are not limited to the following:
1) Mechanisms of inflammatory mediators in IBD development.
2) New insights into the immunoregulatory role of immune cells (including monocytes, macrophages, myeloid-derived suppressor cells [MDSCs], neutrophils, and dendritic cells [DCs]) and microorganisms in human IBD and animal models of colitis.
3) Relevance of understanding the contribution of immune responses for IBD and CAC therapies.
4) New molecular mechanism of IBD and Colitis-associated colorectal cancer modulated by immune cells.
The immune system plays important role in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer. IBD comprised of Crohn’s disease and ulcerative colitis is a manifestation of a dysregulated immune response against the intestinal mucosa. Moreover, Colitis-associated colorectal cancer (CAC) is considered the most serious complication of IBD.
Immune cells are the component of the intestinal microenvironment, they exert specific functions in intestinal tissue during IBD and CAC. They can secrete inflammatory cytokines, exosomes, and other cell factors. Also, immune cells could modulate other cell functions such as fibroblast in cell contact-dependent manners. The immunomodulatory role of immune cells to intestinal epithelial cells is essential to maintain intestinal tissue local immune homeostasis in infectious diseases and tumors. However, the molecular mechanisms underlying the complex functions between immune cells and intestinal epithelial cells in CAC immune surveillance and tumor evasion have not been identified.
This research topic aims to provide a comprehensive overview of immune cell roles in modulating intestinal epithelial cell functions in colon tissue immunopathology, such as inflammation, fibrosis, tumor, and other immune disorders, with particular focus on intestinal microorganism, cellular and molecular mechanisms driving tissue immuno-pathogenesis.
We welcome the submission of Original Research and Review articles that examine the role of the immune microenvironment in the development of IBD and CAC by modulating inflammatory factors and intestinal microorganisms. Subtopics include but are not limited to the following:
1) Mechanisms of inflammatory mediators in IBD development.
2) New insights into the immunoregulatory role of immune cells (including monocytes, macrophages, myeloid-derived suppressor cells [MDSCs], neutrophils, and dendritic cells [DCs]) and microorganisms in human IBD and animal models of colitis.
3) Relevance of understanding the contribution of immune responses for IBD and CAC therapies.
4) New molecular mechanism of IBD and Colitis-associated colorectal cancer modulated by immune cells.