This Topic is intended to provide a current and up to date analysis of research in the field of oncogenic human herpesvirus biology. It is intended for an audience made up of senior undergraduate students, graduate students, medical students, residents, faculty and senior professors in the field of oncogenic virus research. The topic will address current findings in the field of the human oncogenic human herpesviruses from genome replication strategies, persistence of the genome to newly replicated daughter cells, entry of the virus in susceptible cells and consequences of the infection process. Additional areas will include viral antigen control of cell proliferation, cell cycle control and apoptosis, reactivation and lytic replication strategies that are important for generation of new viral progeny and how these strategies are linked to establishment of latency establishment and transformation of infected cells. The important links in post-translational modification of specific viral antigens and their role in regulating cellular and viral processes important for long term persistence and survival of the virus in the infected hosts will be described. Furthermore, we will address the inflammatory response to infection by these virus and their contribution to pathogenesis associated with a number of human malignancies including nasopharyngeal carcinomas. These chapters should complement each other and allow the readers to have a broad and yet insightful context related to human oncogenic herpesvirus and their strategies for successfully navigating the infected hosts.
This Topic is intended to provide a current and up to date analysis of research in the field of oncogenic human herpesvirus biology. It is intended for an audience made up of senior undergraduate students, graduate students, medical students, residents, faculty and senior professors in the field of oncogenic virus research. The topic will address current findings in the field of the human oncogenic human herpesviruses from genome replication strategies, persistence of the genome to newly replicated daughter cells, entry of the virus in susceptible cells and consequences of the infection process. Additional areas will include viral antigen control of cell proliferation, cell cycle control and apoptosis, reactivation and lytic replication strategies that are important for generation of new viral progeny and how these strategies are linked to establishment of latency establishment and transformation of infected cells. The important links in post-translational modification of specific viral antigens and their role in regulating cellular and viral processes important for long term persistence and survival of the virus in the infected hosts will be described. Furthermore, we will address the inflammatory response to infection by these virus and their contribution to pathogenesis associated with a number of human malignancies including nasopharyngeal carcinomas. These chapters should complement each other and allow the readers to have a broad and yet insightful context related to human oncogenic herpesvirus and their strategies for successfully navigating the infected hosts.